{"id":"W2123781894","doi":"10.1016/j.drup.2007.01.003","title":"Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy","year":2007,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":452,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; Manitoba Medical Service Foundation; Manitoba Health Research Council","keywords":"Cell cycle; Programmed cell death; Context (archaeology); Cell biology; Cyclin-dependent kinase; Biology; Cell growth; Apoptosis; Cancer research; Protein kinase B; Regulator; PI3K/AKT/mTOR pathway; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008901313,0.001013415,0.001885355,0.001180791,0.0003756298,0.001524186,0.001113761,0.001616486,0.003265762],"category_scores_gemma":[0.000645801,0.0003283388,0.0004836676,0.00182573,0.0007642764,0.002190221,0.0006986714,0.003562649,0.002086741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008761249,"about_ca_system_score_gemma":0.001072596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007962179,"about_ca_topic_score_gemma":0.002620029,"domain_scores_codex":[0.9998009,0.00003914656,0.00002401756,0.00003364939,0.00008027283,0.00002190259],"domain_scores_gemma":[0.9996364,0.0001712671,0.00003660926,0.000009519016,0.000115128,0.00003104328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001357711,0.000112005,0.0002033034,0.008010476,0.00008404031,0.000297493,0.00006623732,0.0005412424,0.004514114,0.009844949,0.07541326,0.900777],"study_design_scores_gemma":[0.00004015545,0.00008475153,0.0005218821,0.001241874,0.00008978237,0.0008299716,0.00007951963,0.0001749243,0.0005298332,0.004177838,0.9922123,0.0000172967],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001351046,0.99603,0.0003503562,0.001447654,0.0006342767,0.000004972105,0.00001367451,0.00001377507,0.001370157],"genre_scores_gemma":[0.0006170478,0.996015,0.0007505644,0.0008461326,0.000587277,0.00001099491,0.00002767606,0.000002113852,0.001143178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003265762,"threshold_uncertainty_score":0.01092505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05591776088849937,"score_gpt":0.3349819565211766,"score_spread":0.2790641956326773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}