{"id":"W2123799384","doi":"10.4049/jimmunol.1100978","title":"Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute on Aging; Biotechnology and Biological Sciences Research Council","keywords":"Telomerase; Telomere; Cell biology; T cell; p38 mitogen-activated protein kinases; Senescence; Population; Chemistry; Biology; MAPK/ERK pathway; Signal transduction; Immunology; Immune system; DNA; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137291,0.000237969,0.0001740462,0.0002237916,0.0001401657,0.0002337952,0.0001324098,0.0001625409,0.001935948],"category_scores_gemma":[0.0001174623,0.0001164121,0.0001992445,0.0001694322,0.0001286852,0.0001711315,0.0001702351,0.000358076,0.000548365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001247697,"about_ca_system_score_gemma":0.0001828468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003623644,"about_ca_topic_score_gemma":0.0002725693,"domain_scores_codex":[0.9998734,0.00001630638,0.00001080746,0.00003128498,0.00002661157,0.00004157619],"domain_scores_gemma":[0.9999312,0.00001012211,0.0000161787,0.00001289532,0.00001321001,0.00001635103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002047941,0.00002150199,0.0003797312,0.00003240184,0.000003890485,0.00005217911,0.00002838109,0.00004301755,0.9974942,0.0000648732,0.00002408897,0.001650942],"study_design_scores_gemma":[0.00004586217,0.000948574,0.01354584,0.000007531141,0.00002172597,0.0006618336,0.00007229279,0.0006621738,0.9796358,0.0001302352,0.004261886,0.000006191417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945362,0.002147972,0.00164876,0.00003696987,0.00001574102,0.00002285045,0.0002601043,0.00003724612,0.001294184],"genre_scores_gemma":[0.994606,0.0009458987,0.00111631,0.00004717545,0.00001496347,0.00005680577,0.0005934482,0.00001029971,0.002609174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001935948,"threshold_uncertainty_score":0.006476402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044387115026019,"score_gpt":0.2225545607833356,"score_spread":0.2021106896330754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}