{"id":"W2123799384","doi":"10.4049/jimmunol.1100978","title":"Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute on Aging; Biotechnology and Biological Sciences Research Council","keywords":"Telomerase; Telomere; Cell biology; T cell; p38 mitogen-activated protein kinases; Senescence; Population; Chemistry; Biology; MAPK/ERK pathway; Signal transduction; Immunology; Immune system; DNA; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001315255,0.0002934026,0.0006617864,0.0004208545,0.0002834456,0.000007222701,0.001343854,0.0004968775,0.001940297],"category_scores_gemma":[0.000065135,0.0002039009,0.0001954741,0.0003063983,0.00104977,0.0001983475,0.000283548,0.001463762,0.0006990101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009448767,"about_ca_system_score_gemma":0.000142317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006266765,"about_ca_topic_score_gemma":0.00008859102,"domain_scores_codex":[0.9969714,0.001103054,0.0009676021,0.0002144567,0.00005833961,0.0006851722],"domain_scores_gemma":[0.9981697,0.0002690263,0.000747508,0.0006059546,0.0001826471,0.0000252099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007330001,0.000354469,0.0007300433,0.000009557044,0.0003162261,0.00008572923,0.003040391,0.000004768195,0.9909438,0.0004622877,0.002190569,0.001129085],"study_design_scores_gemma":[0.002799799,0.001125507,0.004066538,0.00007189003,0.0001167914,0.002095667,0.002686084,4.655551e-7,0.97838,0.001103058,0.007300971,0.0002532749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979924,0.01206678,0.0001002049,0.0003130744,0.002604852,0.0001810791,0.000003702478,0.0000309917,0.004775344],"genre_scores_gemma":[0.9934168,0.001396038,0.0001189641,0.0002381964,0.00005297276,0.000003182849,0.000003998875,0.00002639576,0.004743428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01349285,"threshold_uncertainty_score":0.9989721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044387115026019,"score_gpt":0.2225545607833356,"score_spread":0.2021106896330754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}