{"id":"W2123815603","doi":"10.1128/aem.67.5.2292-2297.2001","title":"Applications of Gene Replacement Technology to <i>Streptomyces clavuligerus</i> Strain Development for Clavulanic Acid Production","year":2001,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Research Council Canada; National Science Council","keywords":"Streptomyces clavuligerus; Clavulanic acid; Biology; Mutant; Microbiology; Strain (injury); Gene; Biochemistry; Antibiotics; Amoxicillin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002229701,0.0007488657,0.0004111767,0.0004000186,0.0002059998,0.0004326414,0.0003832096,0.0003762514,0.0006525363],"category_scores_gemma":[0.0003578996,0.0002744193,0.0004313109,0.0003169148,0.0002742593,0.000152411,0.0003775067,0.0007846914,0.0005559383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003600632,"about_ca_system_score_gemma":0.000382681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006373133,"about_ca_topic_score_gemma":0.0008499998,"domain_scores_codex":[0.9996517,0.00007291349,0.00005020785,0.00005645742,0.0001211742,0.00004758891],"domain_scores_gemma":[0.9997407,0.0000529207,0.00009884324,0.00004788986,0.0000215146,0.00003820491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001903999,0.00001273099,0.00009284302,0.00001572441,0.000002857836,0.00004314519,0.000008432555,0.0000753253,0.9981629,0.00009800727,0.00001673965,0.001452252],"study_design_scores_gemma":[0.000007394688,0.0001100188,0.0005931537,0.000003509913,0.00001141919,0.0004323101,0.00001151467,0.000615546,0.996056,0.00002963596,0.002124938,0.000004699122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9140872,0.001420688,0.07856985,0.000364382,0.0001522001,0.0003490329,0.0005401424,0.0008940646,0.003622385],"genre_scores_gemma":[0.9446672,0.001238639,0.04946821,0.00007714391,0.00001914393,0.0001631846,0.001118668,0.0001822982,0.003065597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007488657,"threshold_uncertainty_score":0.002612412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006185846027349157,"score_gpt":0.2188198465814836,"score_spread":0.2126340005541345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}