{"id":"W2123815603","doi":"10.1128/aem.67.5.2292-2297.2001","title":"Applications of Gene Replacement Technology to <i>Streptomyces clavuligerus</i> Strain Development for Clavulanic Acid Production","year":2001,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Research Council Canada; National Science Council","keywords":"Streptomyces clavuligerus; Clavulanic acid; Biology; Mutant; Microbiology; Strain (injury); Gene; Biochemistry; Antibiotics; Amoxicillin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188877,0.0001599896,0.0002718186,0.0001215567,0.00009807215,0.000003202069,0.00007318168,0.0001530934,0.00004649507],"category_scores_gemma":[0.000006751834,0.000132839,0.00003250394,0.0001235293,0.0001581004,0.00001346101,0.00006297902,0.00008413803,0.00002064345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006754506,"about_ca_system_score_gemma":0.00001971356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001562546,"about_ca_topic_score_gemma":0.000003247322,"domain_scores_codex":[0.9989371,0.000006941983,0.000303141,0.0004825761,0.00003401083,0.0002362471],"domain_scores_gemma":[0.9995967,0.00001093512,0.00009334274,0.0002290053,0.000009483819,0.00006049833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002288234,0.000162095,0.0007139316,0.00004066224,0.0000574826,4.376077e-7,0.00006892674,6.622684e-7,0.9428791,0.00006725808,0.0002796699,0.05550091],"study_design_scores_gemma":[0.0004116643,0.0001757443,0.000543448,0.00001021507,0.00003841205,0.0001321585,0.0002481214,2.403042e-7,0.8225819,0.00004060224,0.1756989,0.000118524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946136,0.0004253203,0.0008282438,0.002132606,0.00004608213,0.001700615,0.0001224922,0.00003474303,0.00009629274],"genre_scores_gemma":[0.983827,0.000185808,0.01450398,0.0004354223,0.00008867453,0.00009900887,0.0004464486,0.00001512178,0.0003985243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1754193,"threshold_uncertainty_score":0.5417017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006185846027349157,"score_gpt":0.2188198465814836,"score_spread":0.2126340005541345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}