{"id":"W2123829995","doi":"10.1016/j.cell.2005.08.040","title":"Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation","year":2005,"lang":"en","type":"article","venue":"Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1205,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Core Research for Evolutional Science and Technology; RIKEN; Japan Science and Technology Agency; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Biology; Psychological repression; Homeobox; CDX2; Trophoblast; Cellular differentiation; Embryonic stem cell; Transcription factor; Inner cell mass; Cell biology; Stem cell; Genetics; Lineage (genetic); Embryogenesis; Gene; Embryo; Placenta; Blastocyst; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948052,0.0002426993,0.0001929915,0.0003622466,0.000431425,0.0008792568,0.0003244139,0.0003613414,0.002728306],"category_scores_gemma":[0.0003023931,0.0004387703,0.0002278034,0.0002006392,0.000372586,0.0004939335,0.0005949124,0.0007845606,0.0008495702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008851899,"about_ca_system_score_gemma":0.0003740594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001646858,"about_ca_topic_score_gemma":0.00415566,"domain_scores_codex":[0.9997402,0.00004784113,0.00001979482,0.00004477945,0.00005465683,0.00009273698],"domain_scores_gemma":[0.9997095,0.00009352654,0.00005393351,0.00002891551,0.00002197206,0.0000920445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001103691,0.000008111028,0.0004725131,0.000007849193,0.000002973382,0.00005887479,0.000009129047,0.00003893372,0.9985996,0.0002950392,0.00002970215,0.0003669949],"study_design_scores_gemma":[0.0000157088,0.00003568084,0.01076531,0.000003459326,0.00001108069,0.0002986717,0.00007263677,0.001035018,0.9856102,0.0001128453,0.00203442,0.000005009825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933118,0.0008919213,0.001989049,0.00009956029,0.0000276029,0.000009983977,0.000168063,0.0000424386,0.003459585],"genre_scores_gemma":[0.9903151,0.0003367817,0.001615655,0.00007084417,0.0000109534,0.00001408619,0.0005389723,0.00005860342,0.007038875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002728306,"threshold_uncertainty_score":0.00912714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0143555077617401,"score_gpt":0.2688909392031481,"score_spread":0.254535431441408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}