{"id":"W2123883580","doi":"10.1517/14796694.1.1.125","title":"Therapeutic implications of DNA methylation","year":2005,"lang":"en","type":"review","venue":"Future Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenome; Epigenetics; Reprogramming; Epigenomics; Biology; Cancer research; Gene silencing; Cancer epigenetics; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005445289,0.0006107093,0.0008573532,0.001147196,0.0002782126,0.0006917907,0.0008157059,0.001370521,0.003773393],"category_scores_gemma":[0.0005149932,0.0001699605,0.0003318644,0.000714449,0.0006853156,0.0008800233,0.0006240918,0.001602339,0.001957379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008197313,"about_ca_system_score_gemma":0.0005611387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008130253,"about_ca_topic_score_gemma":0.001890584,"domain_scores_codex":[0.9998397,0.00004172055,0.00001211343,0.0000323407,0.0000568125,0.00001726224],"domain_scores_gemma":[0.9998635,0.00006464955,0.00001765757,0.000008111882,0.00003064901,0.00001549064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007892007,0.00005858033,0.0002221061,0.004132364,0.00005875764,0.0005495904,0.0001100387,0.0006241303,0.01055017,0.01657589,0.02345844,0.943581],"study_design_scores_gemma":[0.00002252824,0.00008905656,0.0006149171,0.0008588525,0.00003445461,0.002653875,0.00005183093,0.0001505847,0.003688236,0.006580577,0.9852401,0.00001497599],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004054933,0.9931713,0.0007119001,0.001216502,0.0003335816,0.000006587473,0.00001678595,0.00001375738,0.00412399],"genre_scores_gemma":[0.005743423,0.9883857,0.0008827157,0.000693141,0.0003359551,0.0000182697,0.00003018833,0.000004309435,0.003906444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003773393,"threshold_uncertainty_score":0.01262325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04446095228224609,"score_gpt":0.3873035522682998,"score_spread":0.3428425999860537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}