{"id":"W2123889466","doi":"10.1038/bjc.2012.160","title":"Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study","year":2012,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Cancer Care Ontario; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; Sahlgrenska Universitetssjukhuset; Cancer Care Ontario; Akademiska Sjukhuset; Odense Universitetshospital; Mayo Clinic; Istituto Toscano Tumori; Lunds Universitet; ZonMw; Ministerio de Ciencia e Innovación; National Institute for Health and Care Research; Uppsala Universitet; Cancer Australia; National Health and Medical Research Council; Cancer Research UK; University of Pennsylvania; Susan G. Komen; Deutsches Krebsforschungszentrum; Royal Marsden NHS Foundation Trust; Medical Research Council; Breast Cancer Research Foundation; National Breast Cancer Foundation","keywords":"Methylenetetrahydrofolate reductase; Ovarian cancer; Breast cancer; Oncology; Genotype; Mutation; Medicine; Internal medicine; Genetics; Cancer research; Gynecology; Biology; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005546748,0.0001335234,0.0002537132,0.00007628078,0.0000625051,0.00004883121,0.00008931981,0.0001214657,0.00003144589],"category_scores_gemma":[0.0001386876,0.0001394256,0.00004009778,0.0001266031,0.00006749947,0.00005039971,0.00003985929,0.0001867884,1.724118e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002267222,"about_ca_system_score_gemma":0.0002275178,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.009898346,"about_ca_topic_score_gemma":0.02870903,"domain_scores_codex":[0.9986054,0.0001724929,0.0004849721,0.0002234371,0.0002921725,0.0002214719],"domain_scores_gemma":[0.9986215,0.00004229452,0.0007686256,0.0001151026,0.0003402494,0.0001122516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001337537,0.0002484318,0.902231,0.00001514152,0.0007422987,0.00002670362,0.003079536,0.0004654799,0.01461734,6.702161e-7,0.0009647744,0.07627109],"study_design_scores_gemma":[0.00798805,0.0002131247,0.9824523,0.0002457294,0.0002826072,0.0001359192,0.0009438078,0.00005715294,0.006038093,0.00001225941,0.001447082,0.0001838624],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815103,0.01669277,0.0001016293,0.0002644894,0.0002849265,0.0002271063,0.0008746802,0.000002366123,0.00004170508],"genre_scores_gemma":[0.9950676,0.00356209,0.0006208354,0.00007800399,0.0004985303,0.00002743076,0.00002317199,0.00002403021,0.0000983317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08022131,"threshold_uncertainty_score":0.9966948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006185870280546171,"score_gpt":0.2531326242416453,"score_spread":0.2469467539610991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}