{"id":"W2123891770","doi":"10.1210/en.2014-1232","title":"Circadian Dynamics of the Cone-Rod Homeobox (CRX) Transcription Factor in the Rat Pineal Gland and Its Role in Regulation of Arylalkylamine N-Acetyltransferase (AANAT)","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Faculty of Health and Medical Sciences, University of Western Australia; Rigshospitalet; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; H. Lundbeck A/S; Lundbeckfonden; Augustinus Fonden; Novo Nordisk; Copenhagen Graduate School for Nanoscience and Nanotechnology","keywords":"Pineal gland; Internal medicine; Melatonin; Biology; Endocrinology; Pinealocyte; Circadian rhythm; Gene knockdown; Messenger RNA; Cell biology; Transcription factor; Homeobox; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007806315,0.0001496187,0.0001357298,0.0002723875,0.0001590958,0.0002472857,0.00009693897,0.0001207894,0.0007457216],"category_scores_gemma":[0.00008035399,0.0001126718,0.0001940033,0.0001240907,0.00016833,0.0001468012,0.0001243113,0.0002650907,0.0001765055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002619722,"about_ca_system_score_gemma":0.0002945611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002191816,"about_ca_topic_score_gemma":0.00286294,"domain_scores_codex":[0.999939,0.000003592696,0.000004238319,0.00002228838,0.00001585979,0.00001495781],"domain_scores_gemma":[0.9999119,0.000004375894,0.00002770201,0.000008473196,0.00001789663,0.00002969221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001390135,0.00001574287,0.001397216,0.00001950048,0.000003472402,0.00004415847,0.00003413848,0.0000270248,0.9962339,0.0001136671,0.00004254859,0.001929575],"study_design_scores_gemma":[0.00003564352,0.0005333962,0.3067561,0.00002244472,0.00005665465,0.0004050148,0.0002221595,0.00160402,0.6852841,0.0002564697,0.004793546,0.00003025061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914981,0.004002873,0.002594804,0.00009512253,0.00005422121,0.00001135938,0.0005074201,0.00007923129,0.00115695],"genre_scores_gemma":[0.9944927,0.001289641,0.001113195,0.00004042866,0.00002326375,0.00002461612,0.000423181,0.00002027684,0.002572786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002191816,"threshold_uncertainty_score":0.004358172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480453655494999,"score_gpt":0.2295069928058854,"score_spread":0.2147024562509355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}