{"id":"W2123891770","doi":"10.1210/en.2014-1232","title":"Circadian Dynamics of the Cone-Rod Homeobox (CRX) Transcription Factor in the Rat Pineal Gland and Its Role in Regulation of Arylalkylamine N-Acetyltransferase (AANAT)","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Faculty of Health and Medical Sciences, University of Western Australia; Rigshospitalet; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; H. Lundbeck A/S; Lundbeckfonden; Augustinus Fonden; Novo Nordisk; Copenhagen Graduate School for Nanoscience and Nanotechnology","keywords":"Pineal gland; Internal medicine; Melatonin; Biology; Endocrinology; Pinealocyte; Circadian rhythm; Gene knockdown; Messenger RNA; Cell biology; Transcription factor; Homeobox; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458679,0.0001222865,0.0002548745,0.0001740397,0.00004265148,0.000008143437,0.0002069289,0.0000808417,0.0000274309],"category_scores_gemma":[0.0001725789,0.00008655444,0.00005147947,0.0003090372,0.0001904666,0.00009836622,0.00001663326,0.0002326285,0.000002384263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003042855,"about_ca_system_score_gemma":0.00002882603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001325252,"about_ca_topic_score_gemma":0.00172257,"domain_scores_codex":[0.9985693,0.0003920599,0.000359523,0.0002599419,0.000148448,0.0002707896],"domain_scores_gemma":[0.9993635,0.0002299111,0.00009314407,0.0002635356,0.00001871342,0.00003113181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008151765,0.00009448004,0.04410325,0.00005166737,0.000003504191,0.000008890015,0.00303333,0.0001502385,0.824695,0.1227832,0.00000518453,0.004989761],"study_design_scores_gemma":[0.001740832,0.0001338215,0.6051787,0.00002132894,0.000008213266,0.0001039331,0.000186583,0.004483157,0.3866988,0.0007181598,0.0006228907,0.0001035673],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969524,0.0002366686,0.00006681661,0.001534797,0.0001996056,0.0003522676,0.00004082311,0.000008365164,0.0006083071],"genre_scores_gemma":[0.999561,0.0001637235,0.00000578675,0.0001537596,0.00002718606,0.00001330123,0.000006155763,0.000009855643,0.00005919054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5610755,"threshold_uncertainty_score":0.3529588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480453655494999,"score_gpt":0.2295069928058854,"score_spread":0.2147024562509355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}