{"id":"W2123935496","doi":"10.1128/mcb.22.7.1998-2010.2002","title":"Regulation of Insulin-Like Growth Factor Type I (IGF-I) Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and Motility in PTP-1B-Deficient Fibroblasts","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Higher Education Authority; Enterprise Ireland; Wellcome Trust","keywords":"Biology; Signal transduction; Cell biology; Growth factor; Protein kinase B; Insulin-like growth factor; Protein tyrosine phosphatase; Molecular biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002062657,0.0003270512,0.0004655623,0.00009504201,0.00006095454,0.00001416524,0.0001428962,0.0003883699,0.00005262128],"category_scores_gemma":[0.0003163266,0.0003093969,0.00006242078,0.0002225379,0.000397119,0.00001820456,0.0002631451,0.0001536727,0.000001890583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000206647,"about_ca_system_score_gemma":0.00003129896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002140182,"about_ca_topic_score_gemma":0.00001117274,"domain_scores_codex":[0.9980516,0.0002964942,0.0004476192,0.0007258123,0.0001407524,0.0003377227],"domain_scores_gemma":[0.9989954,0.00003769038,0.0002883263,0.0004065928,0.0001306743,0.0001413234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005351694,0.0004722344,0.001394722,0.0001975678,0.00003522473,0.000001854067,0.00005269267,0.000003675619,0.9940372,0.00007524387,0.0001213495,0.003073048],"study_design_scores_gemma":[0.002010534,0.00100839,0.002389435,0.00007826413,0.00002368837,0.000002282976,0.00001226149,0.0002203376,0.9936376,0.0000701146,0.0002840493,0.0002631099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709899,0.02617429,0.001303026,0.00007036521,0.00007711902,0.0006834769,0.0006792776,0.00001226242,0.00001023699],"genre_scores_gemma":[0.9974574,0.0008567269,0.0004717912,0.00003991296,0.00001503896,0.00003930015,0.001059902,0.00002835882,0.00003159394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02646743,"threshold_uncertainty_score":0.9999358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00679414532009145,"score_gpt":0.2089193782720918,"score_spread":0.2021252329520004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}