{"id":"W2123935496","doi":"10.1128/mcb.22.7.1998-2010.2002","title":"Regulation of Insulin-Like Growth Factor Type I (IGF-I) Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and Motility in PTP-1B-Deficient Fibroblasts","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Higher Education Authority; Enterprise Ireland; Wellcome Trust","keywords":"Biology; Signal transduction; Cell biology; Growth factor; Protein kinase B; Insulin-like growth factor; Protein tyrosine phosphatase; Molecular biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126145,0.0004070303,0.0002295702,0.0001633401,0.0001303147,0.0003032676,0.000166266,0.0002265026,0.0006470475],"category_scores_gemma":[0.0001001756,0.0001805213,0.0002546835,0.0001034724,0.0001720274,0.0001541848,0.0001602083,0.0005245406,0.0002445432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002877229,"about_ca_system_score_gemma":0.0001457671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000804417,"about_ca_topic_score_gemma":0.0008588969,"domain_scores_codex":[0.9998779,0.00001699272,0.00001734057,0.00003328385,0.00003096325,0.00002344761],"domain_scores_gemma":[0.9999233,0.00001193869,0.00002756668,0.000009194307,0.000007267408,0.00002066274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004362554,0.000007836831,0.00007535562,0.00001150426,0.000002123176,0.00002552404,0.000005146553,0.00002535385,0.9995078,0.00002653513,0.00000777792,0.0002613671],"study_design_scores_gemma":[0.00002363572,0.000218624,0.005243157,0.000004369597,0.00001367381,0.000294209,0.00001949359,0.001019047,0.9919905,0.00002740861,0.0011415,0.00000425765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949703,0.001870521,0.002176593,0.00005843318,0.00002691208,0.00001547556,0.0002959275,0.00004470474,0.0005412441],"genre_scores_gemma":[0.9955956,0.000996697,0.001694413,0.00002362289,0.000005654656,0.00002969212,0.0003867513,0.00001090797,0.001256614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000804417,"threshold_uncertainty_score":0.002164543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00679414532009145,"score_gpt":0.2089193782720918,"score_spread":0.2021252329520004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}