{"id":"W2123954468","doi":"10.1093/nar/gku628","title":"CRISPR-Cas: an efficient tool for genome engineering of virulent bacteriophages","year":2014,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Biology; CRISPR; Virulence; Genome; Bacteriophage; Genome engineering; Cas9; Genetics; Genome editing; Gene; Computational biology; Synthetic biology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008915787,0.0001308414,0.0001629702,0.0001147381,0.00007405783,0.00003051518,0.0003056126,0.0001220379,0.00003151837],"category_scores_gemma":[0.0002640669,0.0001299016,0.00008443247,0.0001137133,0.00005976987,0.00000317538,0.0001531217,0.0001246381,0.000008499981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002132015,"about_ca_system_score_gemma":0.00003126097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007514572,"about_ca_topic_score_gemma":0.000002199758,"domain_scores_codex":[0.9987149,0.00004370356,0.0002137585,0.0003352783,0.0002590242,0.0004332853],"domain_scores_gemma":[0.9991345,0.00004242816,0.00002457125,0.0004894898,0.0001959137,0.0001130588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005261679,0.00005872411,0.0001627046,0.0001107652,0.00002260832,4.866752e-7,0.000105216,0.009430392,0.9865288,0.0001565178,0.00007931503,0.003291843],"study_design_scores_gemma":[0.0007056724,0.00116425,0.02224645,0.00002449668,0.00001106054,0.000006334806,0.00009011802,0.03861622,0.8941014,0.0000174408,0.0427473,0.0002692796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9073512,0.0002803734,0.09176332,0.00003398338,0.00008997166,0.0002916611,0.00002309649,0.00001586006,0.0001505229],"genre_scores_gemma":[0.9929081,0.00004836865,0.006422684,0.00001596194,0.0003113714,0.00005676327,0.00004549468,0.00004326291,0.0001479837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09242744,"threshold_uncertainty_score":0.5297235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871726419906721,"score_gpt":0.3496555636849159,"score_spread":0.3309382994858487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}