{"id":"W2123967889","doi":"10.3324/haematol.12212","title":"Characterization of compound 584, an Abl kinase inhibitor with lasting effects","year":2008,"lang":"en","type":"article","venue":"Haematologica","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Centre National de la Recherche Scientifique; European Commission","keywords":"Nilotinib; Dasatinib; Tyrosine kinase; Imatinib; ABL; Chemistry; LYN; Kinase; Bosutinib; Proto-oncogene tyrosine-protein kinase Src; Tyrosine-kinase inhibitor; Pharmacology; Imatinib mesylate; IC50; Cancer research; Molecular biology; Biochemistry; Biology; In vitro; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175478,0.0004089163,0.0002268469,0.0002835923,0.000108772,0.0001539085,0.0003178683,0.0002475258,0.003788832],"category_scores_gemma":[0.0002586127,0.00008516594,0.0002385519,0.0001754214,0.0001383018,0.0001633186,0.000140684,0.0003062422,0.001222333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002356188,"about_ca_system_score_gemma":0.0003800425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004541379,"about_ca_topic_score_gemma":0.0002829118,"domain_scores_codex":[0.9999307,0.000007950393,0.000004529194,0.00001331562,0.00002680958,0.00001661496],"domain_scores_gemma":[0.9999112,0.00001638989,0.00001884818,0.000006039385,0.00002904517,0.00001843169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003533166,0.0001463709,0.0005536175,0.0001433524,0.00001825407,0.0002206207,0.00001834394,0.0012316,0.9838797,0.0001686923,0.0002564139,0.01300967],"study_design_scores_gemma":[0.0002293899,0.004149323,0.004131086,0.00002017677,0.00007268845,0.001177845,0.00002665288,0.00258935,0.9721951,0.0001946389,0.01519705,0.00001679587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97991,0.003869735,0.006731586,0.0001580235,0.00004283988,0.0002085959,0.001855979,0.00008541873,0.007137748],"genre_scores_gemma":[0.9798369,0.001860673,0.006581871,0.0001140346,0.00002736363,0.0001353293,0.005083554,0.00004867922,0.006311705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003788832,"threshold_uncertainty_score":0.01267487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235335089522569,"score_gpt":0.2493130154330397,"score_spread":0.226959664537814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}