{"id":"W2123967889","doi":"10.3324/haematol.12212","title":"Characterization of compound 584, an Abl kinase inhibitor with lasting effects","year":2008,"lang":"en","type":"article","venue":"Haematologica","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Centre National de la Recherche Scientifique; European Commission","keywords":"Nilotinib; Dasatinib; Tyrosine kinase; Imatinib; ABL; Chemistry; LYN; Kinase; Bosutinib; Proto-oncogene tyrosine-protein kinase Src; Tyrosine-kinase inhibitor; Pharmacology; Imatinib mesylate; IC50; Cancer research; Molecular biology; Biochemistry; Biology; In vitro; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005375145,0.0001614064,0.0004570101,0.00006686888,0.00009598961,0.000004996516,0.00005753919,0.00009025579,0.00006260074],"category_scores_gemma":[0.00007339488,0.0001095227,0.00003983563,0.0001677146,0.0001353671,0.00009696541,0.00002625724,0.0001053823,0.00003022208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001108499,"about_ca_system_score_gemma":0.0001263063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002612609,"about_ca_topic_score_gemma":0.000005730175,"domain_scores_codex":[0.9990407,0.00005687441,0.0002312938,0.000250061,0.0002158119,0.0002052457],"domain_scores_gemma":[0.9992717,0.0000866719,0.0001669379,0.0002805545,0.00008090493,0.0001132389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001452758,0.001961161,0.3196981,0.001439032,0.0002354145,0.01047365,0.001584598,0.000008426368,0.6595056,0.0005555876,0.0001712471,0.002914396],"study_design_scores_gemma":[0.008380678,0.003632265,0.4456694,0.0009851631,0.0002094627,0.008042007,0.00006691654,0.0005285615,0.5314558,0.00002604189,0.0006766614,0.0003270749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979147,0.00004901334,0.0001945077,0.00006871864,0.00005720265,0.0004882633,0.000004910334,0.0001134558,0.001109216],"genre_scores_gemma":[0.9971874,0.00002136489,0.002311147,0.0001098506,0.00006009577,0.00003318356,0.0001264952,0.0000194035,0.0001311055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1280499,"threshold_uncertainty_score":0.4466208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235335089522569,"score_gpt":0.2493130154330397,"score_spread":0.226959664537814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}