{"id":"W2124012346","doi":"10.1093/annonc/mdp019","title":"Intrathecal trastuzumab and thiotepa for leptomeningeal spread of breast cancer","year":2009,"lang":"en","type":"letter","venue":"Annals of Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Trastuzumab; ThioTEPA; Intrathecal; Breast cancer; Oncology; Internal medicine; Cancer; Chemotherapy; Surgery; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248586,0.0002491784,0.001182836,0.0001469871,0.00002491505,0.00000345909,0.00008430469,0.0006466568,0.0001358072],"category_scores_gemma":[0.00002901071,0.0001923403,0.0002492917,0.00006838193,0.0002115762,0.00002449804,0.00002452427,0.0004604836,0.000001189384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005462739,"about_ca_system_score_gemma":0.0004026257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002085032,"about_ca_topic_score_gemma":0.00002760024,"domain_scores_codex":[0.9986265,0.00008183967,0.0004502898,0.0003139849,0.0001850766,0.0003423632],"domain_scores_gemma":[0.9987906,0.0003004009,0.0003599315,0.0002233204,0.0002470618,0.0000786387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006608026,0.0003461369,0.0001916695,0.0004075973,0.0007200378,0.0001946546,0.0001485454,7.009942e-7,0.0001587606,0.00006545395,0.6693224,0.3277833],"study_design_scores_gemma":[0.003581784,0.01329982,0.01058141,0.000346936,0.001029652,0.0006099108,0.00003925892,0.00001395255,0.001332628,0.0005897449,0.9683645,0.0002104326],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03873803,0.002873269,0.0000624639,0.9541889,0.0002221415,0.0009149501,0.001469764,0.00001600097,0.001514427],"genre_scores_gemma":[0.2061048,0.004421849,0.004886267,0.7768893,0.004955558,0.0002509372,0.0008547322,0.0001081156,0.001528508],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3275729,"threshold_uncertainty_score":0.784341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07736218046749738,"score_gpt":0.4060432343622379,"score_spread":0.3286810538947406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}