{"id":"W2124012346","doi":"10.1093/annonc/mdp019","title":"Intrathecal trastuzumab and thiotepa for leptomeningeal spread of breast cancer","year":2009,"lang":"en","type":"letter","venue":"Annals of Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Trastuzumab; ThioTEPA; Intrathecal; Breast cancer; Oncology; Internal medicine; Cancer; Chemotherapy; Surgery; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004456609,0.0005281037,0.0008026307,0.0005888582,0.001405087,0.0008428656,0.0009172168,0.009638367,0.002540734],"category_scores_gemma":[0.004682044,0.0004330183,0.000918055,0.0005715428,0.0009571976,0.001086774,0.000396331,0.005891295,0.0009669372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003062992,"about_ca_system_score_gemma":0.001473511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004248684,"about_ca_topic_score_gemma":0.01268337,"domain_scores_codex":[0.9996533,0.00009939229,0.00003609571,0.00003552191,0.0000755769,0.0001000323],"domain_scores_gemma":[0.9989734,0.0005871062,0.00008702569,0.0000484261,0.00007268287,0.0002313715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.001435775,0.0003759373,0.02117752,0.0002947437,0.0001481765,0.7837464,0.0003273351,0.001299212,0.003319771,0.003498099,0.137453,0.04692407],"study_design_scores_gemma":[0.001492065,0.001626989,0.04129444,0.0005072378,0.0004966166,0.7419522,0.0008462791,0.01110465,0.004552211,0.01170153,0.1843077,0.000118],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2156698,0.0203533,0.00245265,0.6603457,0.0144248,0.0002131691,0.0003333023,0.0002596024,0.08594771],"genre_scores_gemma":[0.781436,0.01326271,0.002152066,0.1367303,0.04063595,0.0001473669,0.000217626,0.00008576993,0.02533228],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009638367,"threshold_uncertainty_score":0.02222365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07736218046749738,"score_gpt":0.4060432343622379,"score_spread":0.3286810538947406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}