{"id":"W2124013083","doi":"10.2337/db11-0101","title":"Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Canadian Institutes of Health Research","keywords":"FOXO1; Sirtuin 1; NAD+ kinase; Endocrinology; Internal medicine; Acetylation; Biology; Protein kinase B; Chemistry; Cell biology; Phosphorylation; Downregulation and upregulation; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993979,0.0004971014,0.0003389361,0.0001929208,0.000111382,0.0002058109,0.0002473689,0.0002142633,0.002180584],"category_scores_gemma":[0.0001418565,0.0001263067,0.0005121122,0.000196965,0.000229526,0.0001901127,0.0001569262,0.0006932733,0.0003545137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001909651,"about_ca_system_score_gemma":0.0001890832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001889797,"about_ca_topic_score_gemma":0.0004501418,"domain_scores_codex":[0.9999101,0.00001411786,0.000008079293,0.00001921382,0.0000250096,0.00002335911],"domain_scores_gemma":[0.9999162,0.00001420429,0.00003205642,0.000009623469,0.000006834508,0.00002113098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005580716,0.0001480542,0.0003220846,0.0001230685,0.00002611761,0.00003849702,0.00001255981,0.000128112,0.9939329,0.00007544636,0.000165465,0.004469604],"study_design_scores_gemma":[0.0001996002,0.002950203,0.01037875,0.00001712293,0.00007118703,0.0001898379,0.00003236964,0.001223734,0.9801363,0.00009690636,0.00469447,0.000009581569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882801,0.004936202,0.003323455,0.0003277889,0.0002398011,0.00003713982,0.000460434,0.0002384603,0.002156705],"genre_scores_gemma":[0.9917924,0.002586855,0.002805978,0.000182633,0.00006161761,0.00004440208,0.0006688625,0.00003216763,0.001825088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002180584,"threshold_uncertainty_score":0.007294774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0240785105506012,"score_gpt":0.2330223788832736,"score_spread":0.2089438683326724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}