{"id":"W2124036673","doi":"10.1086/303055","title":"Polymorphisms in Genes Involved in Folate Metabolism as Maternal Risk Factors for Down Syndrome","year":2000,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":371,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Public Health Service; Centers for Disease Control and Prevention; National Institutes of Health; Medical Research Council Canada; Office of Health and Medical Research; National Heart, Lung, and Blood Institute; Research Down Syndrome","keywords":"MTRR; Methylenetetrahydrofolate reductase; Nondisjunction; Odds ratio; Genetics; Down syndrome; Genotype; Biology; Internal medicine; Endocrinology; Medicine; Gene; Chromosome; Aneuploidy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006074135,0.0001815303,0.0006198894,0.000401104,0.00008363119,0.00003508881,0.0003669553,0.00004159222,0.0002807542],"category_scores_gemma":[0.00003258808,0.0001143194,0.0001876613,0.0003605116,0.0002790783,0.00005794687,0.00003506705,0.0004471856,0.00001678596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007355325,"about_ca_system_score_gemma":0.000115544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013559,"about_ca_topic_score_gemma":0.0001220885,"domain_scores_codex":[0.9982172,0.0001785047,0.0006185718,0.000149876,0.0004203646,0.0004155042],"domain_scores_gemma":[0.9990223,0.000110389,0.000335921,0.0002755005,0.00009195908,0.0001639073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00265671,0.0005548164,0.7738867,0.00003808616,0.0006074664,0.0009524851,0.004154716,0.0007633711,0.07171512,0.00004078127,0.0001613796,0.1444683],"study_design_scores_gemma":[0.002205139,0.003791913,0.9812989,0.00008400082,0.0001520321,0.000481467,0.0006622081,0.0001766537,0.009296379,0.0009318779,0.0007600951,0.0001593405],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970321,0.002311488,0.000008186902,0.0002368452,0.00005467721,0.0002655221,0.00001125807,0.000005562759,0.0000743789],"genre_scores_gemma":[0.9961072,0.002676389,0.0004315109,0.0001426213,0.0001321517,0.000005120228,0.000002720374,0.00003550815,0.000466742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2074121,"threshold_uncertainty_score":0.466181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330680305664118,"score_gpt":0.3090822035994694,"score_spread":0.2857754005428282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}