{"id":"W2124076816","doi":"10.1124/jpet.109.160085","title":"The Combi-Targeting Concept: Selective Targeting of the Epidermal Growth Factor Receptor- and Her2-Expressing Cancer Cells by the Complex Combi-Molecule RB24","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cancer research; Human Epidermal Growth Factor Receptor 2; Epidermal growth factor receptor; Epidermal growth factor; Cancer; Receptor; Cancer cell; Growth factor receptor inhibitor; Chemistry; Cell biology; Biology; Medicine; Internal medicine; Breast cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479145,0.0002772062,0.0002765238,0.0001833379,0.0001236419,0.0004209141,0.0003607847,0.0004643826,0.001514579],"category_scores_gemma":[0.0001242419,0.0001533227,0.000137994,0.0001217205,0.0001814877,0.0004407882,0.000250323,0.0004174701,0.0005454094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002923119,"about_ca_system_score_gemma":0.00013452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001833017,"about_ca_topic_score_gemma":0.0002354741,"domain_scores_codex":[0.9999232,0.00001224035,0.000003384958,0.00001982675,0.00002502973,0.00001633486],"domain_scores_gemma":[0.9999585,0.000006098679,0.00001363788,0.000004384912,0.000005290637,0.00001215282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001797333,0.00005412992,0.00006273574,0.00004417775,0.000008137501,0.0001265037,0.00003407257,0.000254206,0.986426,0.002387798,0.000537798,0.009884736],"study_design_scores_gemma":[0.00009971615,0.0005218712,0.0005762664,0.000004373077,0.00001763147,0.0006642081,0.00001297039,0.004341128,0.9791766,0.0003154599,0.01424962,0.00002008414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9396229,0.004523989,0.03985379,0.0009086623,0.0001552877,0.000265886,0.0004367508,0.0004026138,0.01383006],"genre_scores_gemma":[0.9751741,0.00139027,0.01458923,0.000217857,0.00003273221,0.0001335421,0.0001448751,0.00003234556,0.008285074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001514579,"threshold_uncertainty_score":0.005066812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03608685171019115,"score_gpt":0.3937632421963219,"score_spread":0.3576763904861307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}