{"id":"W2124078457","doi":"10.1080/15476286.2014.996067","title":"Small indels induced by CRISPR/Cas9 in the 5′ region of microRNA lead to its depletion and Drosha processing retardance","year":2014,"lang":"en","type":"article","venue":"RNA Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Memorial University of Newfoundland; National Natural Science Foundation of China","keywords":"Drosha; Biology; microRNA; CRISPR; Indel; Genetics; Dicer; Ribonuclease III; Phenotype; Biogenesis; Small RNA; Cas9; Computational biology; RNA; RNA interference; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852012,0.0001011683,0.0001282495,0.00003787337,0.00002793401,0.000007550011,0.0001388805,0.0001546226,5.597904e-7],"category_scores_gemma":[0.0001001324,0.00008105928,0.00002155876,0.00008270165,0.00003187542,0.000001753929,0.00005005246,0.00008370354,0.00000100726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004874486,"about_ca_system_score_gemma":0.00001264427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002748382,"about_ca_topic_score_gemma":0.00006852689,"domain_scores_codex":[0.9993218,0.00007159853,0.0001642554,0.0002404909,0.00003095668,0.0001708698],"domain_scores_gemma":[0.9997012,0.00001524525,0.00005427604,0.0001630436,0.00003740332,0.00002882705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002536686,0.00001259241,0.001710306,0.0000257456,0.000004174727,3.538285e-7,0.0001266787,0.00001856743,0.9825623,0.00004305178,0.0001428766,0.01532799],"study_design_scores_gemma":[0.0004487907,0.00049013,0.01131237,0.00003879447,0.000009224719,0.00003089825,0.00007971277,0.0003077036,0.9718764,0.00008253087,0.01513694,0.0001864613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738573,0.001563099,0.02374745,0.0004861379,0.00004769133,0.0001410302,0.00000332,0.000004674165,0.0001492634],"genre_scores_gemma":[0.9988861,0.0001507943,0.0003883795,0.0004253044,0.00007189772,0.00001427656,0.00002265025,0.000009587919,0.00003098309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02502879,"threshold_uncertainty_score":0.3305502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02021916139238915,"score_gpt":0.3020621476309399,"score_spread":0.2818429862385507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}