{"id":"W2124078457","doi":"10.1080/15476286.2014.996067","title":"Small indels induced by CRISPR/Cas9 in the 5′ region of microRNA lead to its depletion and Drosha processing retardance","year":2014,"lang":"en","type":"article","venue":"RNA Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Memorial University of Newfoundland; National Natural Science Foundation of China","keywords":"Drosha; Biology; microRNA; CRISPR; Indel; Genetics; Dicer; Ribonuclease III; Phenotype; Biogenesis; Small RNA; Cas9; Computational biology; RNA; RNA interference; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652313,0.0004552727,0.0003120929,0.000204486,0.0001638662,0.0003451035,0.0002527047,0.0003191461,0.001393593],"category_scores_gemma":[0.0002069191,0.0002523241,0.0004860554,0.0001184568,0.0002581026,0.0001879768,0.0002911243,0.0008476744,0.0006364977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002014335,"about_ca_system_score_gemma":0.000174739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002484576,"about_ca_topic_score_gemma":0.0004638422,"domain_scores_codex":[0.9998005,0.00002291862,0.00003029459,0.0000693509,0.00005346475,0.00002341695],"domain_scores_gemma":[0.9997556,0.00006856836,0.0000830491,0.00004418418,0.00001656805,0.00003205623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001984833,0.00000643517,0.00007075525,0.00001525834,0.000004528062,0.00005266013,0.000003513805,0.00004419777,0.9992415,0.00005896935,0.00001285971,0.0004695602],"study_design_scores_gemma":[0.000002788732,0.00004034716,0.0009422524,0.000001811837,0.00001093526,0.0001785369,0.000003923661,0.0004681005,0.997283,0.00003905874,0.001025898,0.000003406947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468868,0.001120619,0.04670468,0.0001694776,0.0001353683,0.0001004569,0.001096054,0.0008946959,0.002891815],"genre_scores_gemma":[0.9784244,0.0005765609,0.01553038,0.0001075945,0.00001241571,0.00006503504,0.001101741,0.0001872908,0.003994612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001393593,"threshold_uncertainty_score":0.004662037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02021916139238915,"score_gpt":0.3020621476309399,"score_spread":0.2818429862385507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}