{"id":"W2124154990","doi":"10.1093/brain/awr170","title":"A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy","year":2011,"lang":"en","type":"article","venue":"Brain","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":569,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Medical Research Council; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; Parkinson's UK; National Institute for Health and Care Research; Wellcome Trust","keywords":"Idebenone; Leber's hereditary optic neuropathy; Medicine; Optic neuropathy; Visual acuity; Ophthalmology; Randomized controlled trial; Mitochondrial disease; Placebo; Optic nerve; Internal medicine; Mitochondrial DNA; Pathology; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002253796,0.001682343,0.003785835,0.000724642,0.0006495936,0.001057153,0.0008786764,0.002355366,0.006650506],"category_scores_gemma":[0.002691444,0.000812312,0.001904895,0.000385917,0.0012962,0.001069907,0.0005227191,0.002322201,0.0008468509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007800646,"about_ca_system_score_gemma":0.001309904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001012575,"about_ca_topic_score_gemma":0.002556784,"domain_scores_codex":[0.9986058,0.0007994145,0.0001133461,0.0002172908,0.00009596638,0.0001682691],"domain_scores_gemma":[0.9987367,0.0004155128,0.0002483214,0.0001050426,0.0001106914,0.0003836915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9886141,0.00391209,0.0001157879,0.000422552,0.000356191,0.00002627171,0.00002161226,0.00009179249,0.001416991,0.00005858975,0.0002229028,0.004741232],"study_design_scores_gemma":[0.973007,0.02604352,0.0004105858,0.00001589854,0.0000989362,0.000008016764,0.000007221328,0.00009026932,0.0001042103,0.00004046228,0.0001680069,0.000005941734],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767079,0.006543179,0.0009694087,0.001024407,0.001841897,0.00930797,0.0009010536,0.0001759461,0.002528385],"genre_scores_gemma":[0.9772034,0.003480246,0.002426827,0.001705392,0.0008590826,0.009551459,0.0008850238,0.0000270046,0.003861557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006650506,"threshold_uncertainty_score":0.02224815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780303174237608,"score_gpt":0.2418445515812025,"score_spread":0.2240415198388264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}