{"id":"W2124154990","doi":"10.1093/brain/awr170","title":"A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy","year":2011,"lang":"en","type":"article","venue":"Brain","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":569,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Medical Research Council; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; Parkinson's UK; National Institute for Health and Care Research; Wellcome Trust","keywords":"Idebenone; Leber's hereditary optic neuropathy; Medicine; Optic neuropathy; Visual acuity; Ophthalmology; Randomized controlled trial; Mitochondrial disease; Placebo; Optic nerve; Internal medicine; Mitochondrial DNA; Pathology; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001009359,0.0001300561,0.0005284341,0.00008152986,0.00001679576,0.000003274581,0.0001251525,0.0001547927,0.0001997995],"category_scores_gemma":[0.001577858,0.0001087573,0.0002181403,0.00007045547,0.00009693008,0.000002552712,0.00004649769,0.00008817734,0.00001593504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003717926,"about_ca_system_score_gemma":0.00006260032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006384285,"about_ca_topic_score_gemma":0.00006540958,"domain_scores_codex":[0.9982333,0.0008125477,0.0004456553,0.0002574446,0.00008192719,0.0001690886],"domain_scores_gemma":[0.9993562,0.0001556588,0.0001354382,0.0002667603,0.00003488952,0.00005105834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9192054,0.0001645254,0.00001343993,0.000006599018,0.00003900319,0.00003225691,0.0001467401,0.000006840457,0.07855575,0.0003215861,0.001236194,0.0002716901],"study_design_scores_gemma":[0.9888104,0.0006674406,0.00002903432,0.000006669678,0.00002716061,0.00002815565,0.00003430489,0.00009583555,0.009107003,0.0002205913,0.0008568379,0.0001166314],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816999,0.0002232677,0.001334652,0.0001482629,0.001234058,0.001811504,0.000005290793,0.00001090751,0.01353212],"genre_scores_gemma":[0.9951578,0.00003682244,0.001055793,0.0004717332,0.0004690123,0.0002841292,0.00003657612,0.00002238579,0.002465747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06960496,"threshold_uncertainty_score":0.4434995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780303174237608,"score_gpt":0.2418445515812025,"score_spread":0.2240415198388264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}