{"id":"W2124156684","doi":"10.1139/o10-112","title":"MeCP2: structure and functionThis paper is one of a selection of papers published in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.","year":2011,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Experimental Program to Stimulate Competitive Research; National Center for Research Resources; National Institutes of Health","keywords":"Chromatin; MECP2; Nucleosome; Rett syndrome; Biology; Bivalent chromatin; Chromatin remodeling; Genetics; ChIA-PET; Histone; Repressor; Cell biology; DNA; Computational biology; Gene; Transcription factor; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002419987,0.000257098,0.0005513938,0.00004493097,0.00006441057,0.00002546525,0.0001420564,0.0003693165,0.001840587],"category_scores_gemma":[0.0001140898,0.0001878945,0.0000555906,0.00008874803,0.0003527904,0.000008677942,0.0001392746,0.0002108307,2.213761e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000121104,"about_ca_system_score_gemma":0.0002793812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001423269,"about_ca_topic_score_gemma":0.00003334372,"domain_scores_codex":[0.9988244,0.00008828844,0.0004525007,0.0003692158,0.0001243823,0.0001411654],"domain_scores_gemma":[0.9991693,0.00001854316,0.0003934094,0.0001155795,0.000243131,0.00006000058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003460166,0.0004047358,0.001055428,0.04130511,0.001178681,0.000003255743,0.001179838,1.721198e-7,0.504668,0.00003265991,0.02076337,0.4290627],"study_design_scores_gemma":[0.000679894,0.0003062188,0.0005019752,0.001514267,0.0002982441,0.0001641686,0.0002083504,8.271317e-7,0.03327371,0.00008781705,0.9626548,0.0003097486],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04160907,0.9558357,0.000001345829,0.0002762783,0.00013251,0.000294208,0.000219988,0.000001982534,0.001628888],"genre_scores_gemma":[0.04849777,0.9502726,0.00004462863,0.0000932707,0.0001439247,0.00001121453,0.0002462875,0.00001313974,0.0006772174],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9418914,"threshold_uncertainty_score":0.9990718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01726708174109599,"score_gpt":0.2536864984101246,"score_spread":0.2364194166690286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}