{"id":"W2124156684","doi":"10.1139/o10-112","title":"MeCP2: structure and functionThis paper is one of a selection of papers published in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.","year":2011,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Experimental Program to Stimulate Competitive Research; National Center for Research Resources; National Institutes of Health","keywords":"Chromatin; MECP2; Nucleosome; Rett syndrome; Biology; Bivalent chromatin; Chromatin remodeling; Genetics; ChIA-PET; Histone; Repressor; Cell biology; DNA; Computational biology; Gene; Transcription factor; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002884186,0.0007681308,0.0008360059,0.001182586,0.0001837963,0.0007716307,0.0006794449,0.0008151035,0.002087225],"category_scores_gemma":[0.0003824984,0.0002207953,0.0002028815,0.001394516,0.0003405331,0.0009353939,0.0003823863,0.0009492767,0.001980632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007695822,"about_ca_system_score_gemma":0.0008635276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155037,"about_ca_topic_score_gemma":0.001541977,"domain_scores_codex":[0.9999055,0.000009202658,0.00001367336,0.00002002834,0.00004074096,0.00001083135],"domain_scores_gemma":[0.9998939,0.00003111165,0.00002051135,0.000003530124,0.00003494947,0.00001599645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000758419,0.00002808306,0.000249344,0.008558153,0.00003891951,0.0002718353,0.00003652441,0.000313771,0.008678081,0.002618505,0.0267465,0.9523845],"study_design_scores_gemma":[0.0000112611,0.00004657342,0.001270882,0.001174885,0.00005650791,0.002032892,0.00003504252,0.0001058823,0.002829443,0.001132137,0.9912882,0.00001618153],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002230152,0.9981853,0.0001447514,0.0002572701,0.0001644588,0.000003336301,0.0000276202,0.000007072089,0.0009872228],"genre_scores_gemma":[0.001663247,0.9960295,0.0002852432,0.0001539399,0.0001372103,0.000005589251,0.00008088799,0.000002247542,0.001642264],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002087225,"threshold_uncertainty_score":0.006982505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01726708174109599,"score_gpt":0.2536864984101246,"score_spread":0.2364194166690286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}