{"id":"W2124163794","doi":"10.1080/03602530701468391","title":"Comparison of the 17α-Hydroxylase/C17,20-Lyase Activities of Porcine, Guinea Pig and Bovine P450c17 Using Purified Recombinant Fusion Proteins Containing P450c17 Linked to NADPH-P450 Reductase","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism Reviews","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Purdue Pharma (Canada)","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences","keywords":"Recombinant DNA; Guinea pig; Reductase; Biochemistry; Enzyme; Fusion protein; Chemistry; Biology; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003325342,0.0004515839,0.0002736241,0.0004527129,0.0001124907,0.0002895112,0.0001484913,0.0003050539,0.0006501711],"category_scores_gemma":[0.000360455,0.0001784698,0.0005298082,0.0003193652,0.0002090329,0.0001948586,0.0001380981,0.0003731375,0.0004407447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752794,"about_ca_system_score_gemma":0.0001748742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009979274,"about_ca_topic_score_gemma":0.0008055277,"domain_scores_codex":[0.9997945,0.0000458694,0.00001605201,0.00004122445,0.00004895389,0.00005332175],"domain_scores_gemma":[0.9996881,0.00008540011,0.00007390664,0.00002731999,0.00004782409,0.00007753553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002003042,0.00001988037,0.001133083,0.00003862233,0.00002089466,0.00007111447,0.00002347122,0.00005518497,0.9969522,0.00004028718,0.00002558129,0.001419378],"study_design_scores_gemma":[0.00005239256,0.0008080619,0.03856638,0.00001687549,0.0001048671,0.001180905,0.00007328841,0.001320715,0.9530869,0.00005193286,0.004727995,0.000009672553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943024,0.002001282,0.00215061,0.00009575891,0.00002300845,0.00001817156,0.000435443,0.00002614108,0.0009472157],"genre_scores_gemma":[0.9838807,0.002294732,0.004418124,0.0001180474,0.00003047039,0.0000363339,0.006958269,0.00003582545,0.002227455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009979274,"threshold_uncertainty_score":0.002175033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1522192620393169,"score_gpt":0.4590351702811086,"score_spread":0.3068159082417917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}