{"id":"W2124166505","doi":"10.1073/pnas.0601643103","title":"The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bone health and treatments","field":"Medicine","cited_by":532,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Canadian Institutes of Health Research; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Isothermal titration calorimetry; Chemistry; Farnesyl pyrophosphate; Pyrophosphate; Isopentenyl pyrophosphate; Stereochemistry; Mevalonate pathway; Uncompetitive inhibitor; Enzyme; Population; Biochemistry; Non-competitive inhibition; ATP synthase; Biosynthesis; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738522338568411,"score_gpt":0.2989866602387146,"score_spread":0.2816014368530305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}