{"id":"W2124176874","doi":"10.1172/jci64484","title":"Mutant huntingtin impairs immune cell migration in Huntington disease","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Neurological Disorders and Stroke; Medical Research Council; University of California, San Francisco; National Institutes of Health; Concordia University; University of Leicester; Multiple Sclerosis Society; Gladstone Institutes; National Institute on Drug Abuse; CHDI Foundation","keywords":"Huntingtin; Immune system; Microglia; Biology; Neurodegeneration; Mutant; Huntington's disease; Cell biology; Huntingtin Protein; Immunology; Inflammation; Disease; Genetics; Medicine; Pathology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336603,0.0003220052,0.0002190929,0.0002039813,0.0001681716,0.0001720079,0.0001051936,0.0002607519,0.000585416],"category_scores_gemma":[0.0001129756,0.0001335744,0.0001421902,0.00006586659,0.0002034999,0.0001134277,0.0001657299,0.0002650086,0.0001816715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000181547,"about_ca_system_score_gemma":0.000133896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006613847,"about_ca_topic_score_gemma":0.001169304,"domain_scores_codex":[0.9999142,0.00002133973,0.000009442591,0.00001218628,0.00001555324,0.00002734817],"domain_scores_gemma":[0.9999236,0.00001119991,0.00001715091,0.000005860767,0.000007426439,0.00003476689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002630085,0.00005197652,0.0006180402,0.00001789539,0.00000533155,0.0002611161,0.00003051399,0.0000258754,0.9972497,0.00003406897,0.00003924254,0.001403196],"study_design_scores_gemma":[0.0001504569,0.002824127,0.128017,0.00005055889,0.000075663,0.004283253,0.00026369,0.001558568,0.8578553,0.0003273552,0.004577942,0.00001609048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989485,0.0005058148,0.0001725551,0.00001952008,0.000007229839,0.000004580863,0.00002427227,0.00001569026,0.0003017388],"genre_scores_gemma":[0.9981157,0.0005407599,0.0003469296,0.00003702037,0.000005056608,0.00001164523,0.00007947493,0.000007586317,0.0008558541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006613847,"threshold_uncertainty_score":0.00195837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07844389210649401,"score_gpt":0.3546007779199818,"score_spread":0.2761568858134878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}