{"id":"W2124197527","doi":"10.1099/mic.0.2008/023200-0","title":"Burkholderia cenocepacia-induced delay of acidification and phagolysosomal fusion in cystic fibrosis transmembrane conductance regulator (CFTR)-defective macrophages","year":2008,"lang":"en","type":"article","venue":"Microbiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; University of Texas Southwestern Medical Center; Cystic Fibrosis Foundation","keywords":"Burkholderia cenocepacia; Cystic fibrosis transmembrane conductance regulator; Vacuole; Microbiology; Intracellular; Intracellular parasite; Cystic fibrosis; Phagolysosome; Biology; Lysosome; Phagocytosis; Phagosome; Burkholderia; Cell biology; Bacteria; Cytoplasm; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001765572,0.0002120618,0.0005779851,0.0002322059,0.00008217949,0.000004565877,0.0001061946,0.0002023581,0.0001288111],"category_scores_gemma":[0.0002080036,0.0001872646,0.00007116265,0.0003545989,0.0005051869,0.00009902667,0.000043564,0.0002371056,0.00001279329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009713165,"about_ca_system_score_gemma":0.0001136222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008206343,"about_ca_topic_score_gemma":0.00007345071,"domain_scores_codex":[0.9984092,0.0001719804,0.0004346186,0.0004904529,0.00009752213,0.0003961905],"domain_scores_gemma":[0.999091,0.0002342879,0.0001314071,0.0002901498,0.0001442738,0.0001088399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001117715,0.0001462404,0.006393876,0.0002056112,0.00003509847,0.00006410147,0.0006408754,0.000004693862,0.9899427,0.00003083118,0.0000661114,0.001352194],"study_design_scores_gemma":[0.002824279,0.0008420037,0.08911968,0.0001573829,0.00003287388,0.001188641,0.0001343107,0.00004300401,0.9049804,0.0000485784,0.0004635689,0.0001652948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953936,0.00327374,0.000152783,0.0002274443,0.00008682913,0.0006467681,0.0001058424,0.00003444622,0.00007853002],"genre_scores_gemma":[0.9958481,0.0003342294,0.003437308,0.00004133247,0.00004334455,0.0000482659,0.0001035168,0.00002482592,0.0001191363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08496226,"threshold_uncertainty_score":0.7636427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878656485451966,"score_gpt":0.2746099774660937,"score_spread":0.255823412611574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}