{"id":"W2124197527","doi":"10.1099/mic.0.2008/023200-0","title":"Burkholderia cenocepacia-induced delay of acidification and phagolysosomal fusion in cystic fibrosis transmembrane conductance regulator (CFTR)-defective macrophages","year":2008,"lang":"en","type":"article","venue":"Microbiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; University of Texas Southwestern Medical Center; Cystic Fibrosis Foundation","keywords":"Burkholderia cenocepacia; Cystic fibrosis transmembrane conductance regulator; Vacuole; Microbiology; Intracellular; Intracellular parasite; Cystic fibrosis; Phagolysosome; Biology; Lysosome; Phagocytosis; Phagosome; Burkholderia; Cell biology; Bacteria; Cytoplasm; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301931,0.0002661876,0.0003413841,0.0001569611,0.0001664286,0.0002460967,0.0001749716,0.0004324812,0.0006291347],"category_scores_gemma":[0.0002209604,0.0001429295,0.0002169894,0.0001027735,0.0002164355,0.0002199024,0.0002685371,0.0004800107,0.0002359268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001923076,"about_ca_system_score_gemma":0.0001919273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006855077,"about_ca_topic_score_gemma":0.0005974692,"domain_scores_codex":[0.9997597,0.00005862236,0.00003862729,0.00003277052,0.00004291849,0.00006732222],"domain_scores_gemma":[0.9998201,0.00003951821,0.00004898657,0.00002742523,0.00002643797,0.0000375859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001897739,0.00002734326,0.0001976248,0.00002187918,0.000002216223,0.00009539722,0.00002122383,0.00002604739,0.9991264,0.00003188913,0.00001214667,0.0002480807],"study_design_scores_gemma":[0.00004963961,0.0009016634,0.01035401,0.000009146971,0.00001076247,0.0007757835,0.000109198,0.0009296945,0.9858187,0.00007781075,0.0009559693,0.000007654397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980487,0.0005982813,0.0007589285,0.00007826074,0.00001867033,0.00001738296,0.0001576018,0.00002616825,0.000296126],"genre_scores_gemma":[0.9982851,0.0002655792,0.0006269785,0.00004409639,0.000005230164,0.00002468098,0.0001635216,0.000006451521,0.0005781951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006855077,"threshold_uncertainty_score":0.00210464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878656485451966,"score_gpt":0.2746099774660937,"score_spread":0.255823412611574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}