{"id":"W2124198277","doi":"10.1128/ec.00103-10","title":"Heterologous Expression of Candida albicans Cell Wall-Associated Adhesins in Saccharomyces cerevisiae Reveals Differential Specificities in Adherence and Biofilm Formation and in Binding Oral Streptococcus gordonii","year":2010,"lang":"en","type":"article","venue":"Eukaryotic Cell","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Dental and Craniofacial Research; National Institutes of Health; Johns Hopkins University","keywords":"Streptococcus gordonii; Candida albicans; Bacterial adhesin; Microbiology; Biology; Biofilm; Corpus albicans; Saccharomyces cerevisiae; Virulence; Fungal protein; Yeast; Bacteria; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007971389,0.0002915988,0.0001156839,0.0001405845,0.00008258405,0.0003019941,0.0001549933,0.0001600495,0.0003627275],"category_scores_gemma":[0.0001194027,0.000118853,0.0002222186,0.0002295671,0.0001226238,0.00009040565,0.0001873828,0.0003460467,0.0002176405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003075108,"about_ca_system_score_gemma":0.0002050034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002431884,"about_ca_topic_score_gemma":0.002428459,"domain_scores_codex":[0.9999202,0.00001125858,0.00001286091,0.00001327586,0.00002219146,0.00002014322],"domain_scores_gemma":[0.9999256,0.00001210008,0.00001731797,0.00001346812,0.00001021465,0.0000212644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004811597,0.00001452919,0.0002496982,0.00001119096,0.000003154465,0.00003526779,0.00001346707,0.00006687342,0.9990736,0.00007826718,0.000010788,0.0003950391],"study_design_scores_gemma":[0.000008745847,0.00009887485,0.008244673,0.000005827441,0.00001828279,0.0002433935,0.00007507253,0.001912147,0.9881699,0.00005242442,0.001165061,0.000005670435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984641,0.0001524123,0.0007749058,0.00001956144,0.000005304246,0.000006482419,0.0002530272,0.00001840181,0.0003057984],"genre_scores_gemma":[0.9956591,0.000235589,0.001974243,0.00001658976,0.000001874907,0.00001212278,0.0008458178,0.00001748625,0.001237167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002431884,"threshold_uncertainty_score":0.004835427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01519039711800678,"score_gpt":0.2511673052447116,"score_spread":0.2359769081267049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}