{"id":"W2124216273","doi":"10.1002/ajmg.a.30747","title":"The adult phenotype in Costello syndrome","year":2005,"lang":"en","type":"article","venue":"American Journal of Medical Genetics Part A","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Institute of Genetics; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Medicine; Malignancy; Endocrine system; Pediatrics; Costello syndrome; Internal medicine; Hormone; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367282,0.0008382098,0.0003861352,0.001132913,0.0005343523,0.0003525107,0.0002262891,0.0007141812,0.002987324],"category_scores_gemma":[0.001921875,0.0002009291,0.0001882196,0.0006290148,0.0005046197,0.0003302238,0.0005739746,0.0004019354,0.0003231708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002147351,"about_ca_system_score_gemma":0.0001863581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001691037,"about_ca_topic_score_gemma":0.0017979,"domain_scores_codex":[0.9997781,0.00001977844,0.00002175686,0.00005045946,0.00004789828,0.00008191683],"domain_scores_gemma":[0.9991797,0.0001506687,0.0002772284,0.00003334115,0.00009691688,0.0002622344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004637517,0.0001178577,0.5792937,0.0001577766,0.00005801483,0.3598912,0.001452375,0.0002847259,0.01186392,0.0006600292,0.002843787,0.04291284],"study_design_scores_gemma":[0.00003451074,0.0004350646,0.2454774,0.00004009711,0.00004539081,0.7495867,0.0004157324,0.0002353925,0.0008466864,0.0002960817,0.002566176,0.00002083137],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962623,0.0007055241,0.0003982172,0.0001665951,0.00002524775,0.00001629205,0.0001384511,0.00003056441,0.002256722],"genre_scores_gemma":[0.9987007,0.0003198625,0.0002805057,0.0001096582,0.00003681495,0.00000916755,0.0001186717,0.000007588043,0.0004169209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002987324,"threshold_uncertainty_score":0.009993613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005508368745535907,"score_gpt":0.2621026609585044,"score_spread":0.2565942922129685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}