{"id":"W2124242809","doi":"10.1039/c4bm00202d","title":"Cellulose-based polyelectrolyte complex nanoparticles for DNA vaccine delivery","year":2014,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Alberta","funders":"Alberta Livestock and Meat Agency; Alberta Crop Industry Development Fund","keywords":"Lipofectamine; Transfection; DNA; Nanoparticle; Polyelectrolyte; Chemistry; Carboxymethyl cellulose; Gene delivery; Cellulose; Conjugate; Biophysics; DNA vaccination; Plasmid; Combinatorial chemistry; Nanotechnology; Biochemistry; Materials science; Polymer; Sodium; Organic chemistry; Biology; Vector (molecular biology); Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002871192,0.000554532,0.0003042867,0.0002623976,0.0001487342,0.0003328879,0.0002589095,0.0004830376,0.0007978798],"category_scores_gemma":[0.0002787532,0.000177493,0.0002574628,0.0002100701,0.0001616324,0.0003670571,0.0001688561,0.0004687146,0.0004447609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007123699,"about_ca_system_score_gemma":0.0005138759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065276,"about_ca_topic_score_gemma":0.001544456,"domain_scores_codex":[0.9998442,0.00002102337,0.00001455768,0.00003957317,0.00005482247,0.00002581574],"domain_scores_gemma":[0.999858,0.00003431751,0.00003764063,0.0000105179,0.00003327417,0.00002622017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001956079,0.0000157516,0.00003855661,0.00005891241,0.000004766464,0.00002636526,0.00000567321,0.0001966135,0.9968621,0.0001467279,0.00004442581,0.002580568],"study_design_scores_gemma":[0.000006765247,0.00004521248,0.0001686388,0.00000334249,0.000006939088,0.00006112822,0.000002793548,0.001096815,0.9966968,0.00002832329,0.001878259,0.000004989727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8585895,0.01664344,0.1143939,0.0005699798,0.0003895244,0.0004296209,0.0007208762,0.0005375042,0.007725672],"genre_scores_gemma":[0.9183254,0.005740492,0.06787801,0.0003334626,0.00007172846,0.0002279654,0.0005753069,0.0001046891,0.006743026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065276,"threshold_uncertainty_score":0.005168617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737698284342835,"score_gpt":0.2573028652784233,"score_spread":0.239925882434995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}