{"id":"W2124252984","doi":"10.2174/1568026054367629","title":"Role of Cation-Chloride-Cotransporters (CCC) in Pain and Hyperalgesia","year":2005,"lang":"en","type":"review","venue":"Current Topics in Medicinal Chemistry","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cotransporter; GABAergic; Inhibitory postsynaptic potential; Chemistry; Nociception; Neuroscience; Depolarization; Nociceptor; Spinal cord; Glycine receptor; Hyperalgesia; Pharmacology; Biophysics; Cell biology; Biochemistry; Medicine; Biology; Glycine; Receptor; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004845937,0.0003177741,0.001271564,0.0001204813,0.00001374136,0.000003609595,0.0001191405,0.0002706544,0.00006858355],"category_scores_gemma":[0.0001128731,0.0002645601,0.0001385483,0.0001990872,0.00007281369,0.00002318761,0.00002006546,0.0006176045,0.000001648716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002208409,"about_ca_system_score_gemma":0.000257522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002922914,"about_ca_topic_score_gemma":0.00001010345,"domain_scores_codex":[0.9983444,0.00004743911,0.0007172338,0.0003696612,0.0002810084,0.0002402343],"domain_scores_gemma":[0.999254,0.00009026628,0.000199936,0.0002902462,0.00003040776,0.0001351453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001247365,0.0002032043,0.00309864,0.01960018,0.00003993393,0.00004987475,0.0001239786,1.124607e-7,0.00001968465,0.00004541602,0.0000163601,0.9767901],"study_design_scores_gemma":[0.002317092,0.0001259563,0.001639729,0.07119433,0.001059037,0.0001366339,0.00021059,0.00005632247,0.0002150019,0.0003715588,0.9221924,0.0004813391],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004685653,0.9942011,0.00001195058,0.00005684633,0.00009741836,0.0004093908,0.00001319786,0.00001094765,0.0005134649],"genre_scores_gemma":[0.003683832,0.9952998,0.0001506069,0.00002123554,0.0003777517,0.00007652411,0.0002472124,0.00002324301,0.0001198608],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9763088,"threshold_uncertainty_score":0.9999807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0385513509255555,"score_gpt":0.3408740506435239,"score_spread":0.3023226997179684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}