{"id":"W2124264670","doi":"10.1128/cvi.00022-15","title":"Protective Efficacy and Pharmacokinetics of Human/Mouse Chimeric Anti-Stx1 and Anti-Stx2 Antibodies in Mice","year":2015,"lang":"en","type":"article","venue":"Clinical and Vaccine Immunology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada); Bausch Health (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"STX2; Monoclonal antibody; Shiga toxin; Antibody; Escherichia coli; Microbiology; Lethal dose; Toxin; Pharmacology; Virology; Biology; Medicine; Immunology; Biochemistry; Toxicology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004685179,0.0008072824,0.0007025509,0.000637085,0.0001940442,0.000485273,0.00041472,0.0008489499,0.0008054367],"category_scores_gemma":[0.0003112588,0.0003145,0.000451285,0.0002579002,0.0003672375,0.0005767734,0.0001349076,0.002008296,0.0003739724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004754021,"about_ca_system_score_gemma":0.000362565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007149667,"about_ca_topic_score_gemma":0.0006846315,"domain_scores_codex":[0.9996229,0.00007658565,0.00001846677,0.00008300508,0.00007172421,0.0001271802],"domain_scores_gemma":[0.9995779,0.00006409034,0.0001171575,0.00004093914,0.00004616945,0.0001538364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004450319,0.0018588,0.0004598481,0.00006994864,0.0000433524,0.00005912175,0.00007128432,0.0007395257,0.985773,0.0001639417,0.0003061756,0.006004615],"study_design_scores_gemma":[0.000682821,0.04801462,0.006148297,0.00002465146,0.0002019894,0.000303386,0.0000485418,0.004552579,0.9364464,0.0001673121,0.003379927,0.00002953518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941021,0.002436838,0.001658489,0.0001615308,0.00007670931,0.00008031716,0.000406002,0.0001570647,0.0009209767],"genre_scores_gemma":[0.9926898,0.001844757,0.001466971,0.0002080952,0.00006255371,0.0001308894,0.0008107979,0.0000539996,0.002732112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008489499,"threshold_uncertainty_score":0.003449321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05235058456239123,"score_gpt":0.3915155014980509,"score_spread":0.3391649169356597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}