{"id":"W2124269993","doi":"10.1124/dmd.107.015669","title":"Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model","year":2007,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Drug Research and Development","funders":"","keywords":"Darbepoetin alfa; Absorption (acoustics); Lymphatic system; Chemistry; Pharmacokinetics; Pharmacology; Biochemistry; Biology; Immunology; Materials science; Hemoglobin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002844117,0.0001575138,0.0003385414,0.0001511138,0.00006034123,0.000006198271,0.00005418568,0.0001319748,0.000009813304],"category_scores_gemma":[0.00008069041,0.00009976779,0.0001055658,0.0002065481,0.0002083695,0.00008378523,0.00002292644,0.0001265673,8.178654e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001589185,"about_ca_system_score_gemma":0.00002050956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005287899,"about_ca_topic_score_gemma":0.000008502904,"domain_scores_codex":[0.9987848,0.00009305825,0.0004678574,0.00020662,0.000298156,0.0001494479],"domain_scores_gemma":[0.999182,0.0001048183,0.0003513165,0.0001894786,0.0001114178,0.00006099835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001973197,0.0005498499,0.0009918058,0.0002872819,0.00004842701,0.000003283095,0.0009562258,0.004336879,0.98588,0.002947255,0.000004726622,0.00202106],"study_design_scores_gemma":[0.004238746,0.001782289,0.3556395,0.001120462,0.001202986,0.0001609513,0.001056491,0.115007,0.5107093,0.008656464,0.000009047851,0.0004167451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969368,0.0004055398,0.001562044,0.0002108864,0.00003774355,0.0006495504,0.00001587389,0.00001882379,0.0001627389],"genre_scores_gemma":[0.9992805,0.0002632625,0.0001911661,0.0001709355,0.00002191038,0.00000929267,0.00002849206,0.00001261927,0.00002180686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4751707,"threshold_uncertainty_score":0.4068412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892456329184869,"score_gpt":0.260322686058651,"score_spread":0.2413981227668023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}