{"id":"W2124280909","doi":"10.1074/jbc.m115.665943","title":"Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; Lupus Research Institute; National Institutes of Health; Lupus Research Alliance; University of Alabama; University of Alabama at Birmingham","keywords":"Cytokine; Receptor; Biology; Cytokine receptor; Signal transduction; Cell biology; Antibody; Cell surface receptor; Immunology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177281,0.0004130646,0.0002071565,0.0001995066,0.00009500563,0.0002357988,0.0001898426,0.0003998841,0.001030301],"category_scores_gemma":[0.0001657261,0.0001224452,0.0002547413,0.0001016493,0.0002039107,0.0001661056,0.0001418317,0.0006159193,0.0004217282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003112784,"about_ca_system_score_gemma":0.0001095676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001846167,"about_ca_topic_score_gemma":0.0002589145,"domain_scores_codex":[0.9998127,0.0000461123,0.00001453728,0.00004468649,0.00004486063,0.00003724909],"domain_scores_gemma":[0.9998691,0.00003654211,0.00003910013,0.00001324322,0.00002264822,0.00001935829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004537042,0.00001954177,0.000085532,0.00002967411,0.000006403012,0.00002066935,0.00000465433,0.00008778969,0.9983146,0.00009143147,0.00002571224,0.001268656],"study_design_scores_gemma":[0.00002056881,0.0001929794,0.0005658634,0.00000368559,0.00001250301,0.0001574279,0.000003382997,0.0004474129,0.9961507,0.00002076424,0.002421873,0.000002913777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540471,0.004673767,0.03769914,0.0001727579,0.00008010806,0.0001544324,0.0002488283,0.0001706117,0.002753183],"genre_scores_gemma":[0.9775481,0.001313584,0.01875933,0.0001672307,0.00002244352,0.00007217548,0.0003741129,0.00003207435,0.001710986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030301,"threshold_uncertainty_score":0.003446698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05755052210380327,"score_gpt":0.3443337450567129,"score_spread":0.2867832229529096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}