{"id":"W2124283874","doi":"10.1139/y2012-060","title":"Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy<sup>1</sup>This article is an invited review for the Journal's Made In Canada section. The authors gratefully acknowledge the training that was acquired at the Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba. We would specifically like to thank Dr. Peter Jones for his mentorship and significant contribution to the research contained within this manuscript.","year":2012,"lang":"en","type":"review","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Sterol; Plant sterols; Cholesterol; Biology; Sterol regulatory element-binding protein; Disease; Ldl cholesterol; Biotechnology; Bioinformatics; Biochemistry; Medicine; Endocrinology; Physiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004726174,0.00038225,0.0007440386,0.001097133,0.0002205349,0.000737072,0.0004242765,0.000679452,0.004166189],"category_scores_gemma":[0.0007782432,0.0001186856,0.0002881127,0.001131893,0.0003152727,0.000467539,0.0002950806,0.0006374263,0.001958443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006363798,"about_ca_system_score_gemma":0.0018997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005147444,"about_ca_topic_score_gemma":0.01033306,"domain_scores_codex":[0.9998479,0.00002598434,0.00002002008,0.00002007415,0.00006341312,0.00002254471],"domain_scores_gemma":[0.9996775,0.0001123047,0.0000426483,0.000006168823,0.0001368704,0.00002436292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001799663,0.00006387485,0.001455874,0.01022509,0.00007724245,0.0004060615,0.00007470526,0.0001279763,0.005087392,0.001873615,0.03234453,0.9480838],"study_design_scores_gemma":[0.0000256535,0.000176625,0.01371666,0.003888099,0.0002606788,0.002987579,0.0002034264,0.00008987846,0.002402673,0.001373855,0.9748386,0.00003621762],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004475504,0.9962549,0.0001300198,0.001054615,0.0005132333,0.0000073191,0.00003906743,0.000007285513,0.001545925],"genre_scores_gemma":[0.001996192,0.996003,0.0002474753,0.000244358,0.000313837,0.000006601354,0.00004559802,0.000001724183,0.001141185],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005147444,"threshold_uncertainty_score":0.01393729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2109001362245492,"score_gpt":0.3388820332823953,"score_spread":0.1279818970578461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}