{"id":"W2124283941","doi":"10.1038/sj.emboj.7601522","title":"PSGL‐1 and mTOR regulate translation of ROCK‐1 and physiological functions of macrophages","year":2007,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Biology; Translation (biology); PI3K/AKT/mTOR pathway; Cell biology; Computational biology; Signal transduction; Genetics; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002517197,0.0003975315,0.0003436566,0.0005757092,0.0003646276,0.0006248665,0.0003095696,0.0003529884,0.001499788],"category_scores_gemma":[0.0003256537,0.0003101116,0.0002714016,0.0002097469,0.0004629823,0.0006038544,0.0004348895,0.0007801775,0.0004897663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007170417,"about_ca_system_score_gemma":0.0003365757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005496096,"about_ca_topic_score_gemma":0.0008755052,"domain_scores_codex":[0.9997341,0.00005531332,0.00001825092,0.00003145278,0.00003666549,0.0001242108],"domain_scores_gemma":[0.9998411,0.00002727247,0.00003711734,0.00001520677,0.00002068206,0.00005861483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003124707,0.00006057945,0.001067214,0.00007332358,0.00001287466,0.000205051,0.00005994121,0.0001835755,0.9905301,0.001261061,0.0003248969,0.003096705],"study_design_scores_gemma":[0.0001779097,0.0003510171,0.03850669,0.00001651465,0.00005070016,0.0004957987,0.0002898584,0.002627364,0.9524322,0.001342762,0.003690651,0.00001855928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918467,0.003785775,0.001139762,0.0005169374,0.0000490714,0.0000144245,0.0002689667,0.00006051136,0.002317959],"genre_scores_gemma":[0.9967248,0.0007786414,0.0004231874,0.00007146492,0.00003272468,0.000027573,0.0002357844,0.00001985303,0.001686091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499788,"threshold_uncertainty_score":0.005202532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976285846064979,"score_gpt":0.2608718653185376,"score_spread":0.2411090068578878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}