{"id":"W2124289149","doi":"10.1158/0008-5472.can-05-3635","title":"Cyclooxygenase-2–Dependent Regulation of E-Cadherin: Prostaglandin E2 Induces Transcriptional Repressors ZEB1 and Snail in Non–Small Cell Lung Cancer","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":285,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Cancer research; Gene knockdown; Paracrine signalling; Biology; Cadherin; Autocrine signalling; Cyclooxygenase; Prostaglandin E2; Metastasis; Cancer; Cell; Cell culture; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008055607,0.0001775563,0.0001337356,0.0001426564,0.0001318434,0.0001967482,0.00008049925,0.0001113771,0.001727601],"category_scores_gemma":[0.00006236466,0.0001189768,0.0001999542,0.000103318,0.0001394607,0.0001162144,0.0001570038,0.0003025831,0.0003617128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001962657,"about_ca_system_score_gemma":0.0001333638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005741286,"about_ca_topic_score_gemma":0.00132591,"domain_scores_codex":[0.9999307,0.00001314744,0.000005512882,0.00001342546,0.00001897244,0.00001823245],"domain_scores_gemma":[0.9999638,0.000005952256,0.000008697205,0.000004512459,0.00000617924,0.00001090654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005270587,0.00001221535,0.0002859466,0.00002430882,0.000002084555,0.0000274423,0.000007548446,0.0000138037,0.9990875,0.00004088017,0.0000323983,0.0004131175],"study_design_scores_gemma":[0.00002106332,0.0001601616,0.02997928,0.000003722178,0.00000922025,0.0003039127,0.0000291362,0.0009184725,0.9659779,0.0000365369,0.002557268,0.000003341835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937696,0.002291991,0.001677555,0.0000952336,0.00002839128,0.00003435174,0.0004105937,0.00006020128,0.001632081],"genre_scores_gemma":[0.9936981,0.0009239257,0.0008193897,0.00005296049,0.000007008764,0.00003987345,0.000634013,0.000009320512,0.003815585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727601,"threshold_uncertainty_score":0.005779445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0324729560858078,"score_gpt":0.3364601835515381,"score_spread":0.3039872274657303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}