{"id":"W2124289149","doi":"10.1158/0008-5472.can-05-3635","title":"Cyclooxygenase-2–Dependent Regulation of E-Cadherin: Prostaglandin E2 Induces Transcriptional Repressors ZEB1 and Snail in Non–Small Cell Lung Cancer","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":285,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Cancer research; Gene knockdown; Paracrine signalling; Biology; Cadherin; Autocrine signalling; Cyclooxygenase; Prostaglandin E2; Metastasis; Cancer; Cell; Cell culture; Endocrinology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041993,0.0001466129,0.0003076045,0.0003275293,0.00008074926,0.00002041276,0.00009227984,0.0001623289,0.0003428877],"category_scores_gemma":[0.00003506694,0.0001282684,0.00004844562,0.0003589789,0.0001538459,0.00009643833,0.00003790716,0.0004586443,0.000003125631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003027307,"about_ca_system_score_gemma":0.0003653857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006026967,"about_ca_topic_score_gemma":0.001797146,"domain_scores_codex":[0.9979838,0.0001474733,0.0003541347,0.0003856928,0.0006947225,0.0004341474],"domain_scores_gemma":[0.9992437,0.00009365944,0.00007848137,0.0002266781,0.0002247615,0.0001327306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006409577,0.000113627,0.2470641,0.001191288,0.00002086324,0.0000408944,0.0008761032,0.0002595247,0.7472994,0.0000842755,0.001299788,0.001109188],"study_design_scores_gemma":[0.002787567,0.000129637,0.6276268,0.0005407799,0.00002604953,0.000004562542,0.0001117763,0.0005721137,0.3672021,0.00007398454,0.0007926603,0.0001319071],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922552,0.004837575,0.00001017679,0.000296738,0.000161638,0.001164241,0.00003706502,0.00001512306,0.001222306],"genre_scores_gemma":[0.9960242,0.0005747981,0.00004010557,0.00002179724,0.0004064138,0.0004951706,0.00002625791,0.00002921193,0.002382041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3805628,"threshold_uncertainty_score":0.9111011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0324729560858078,"score_gpt":0.3364601835515381,"score_spread":0.3039872274657303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}