{"id":"W2124307065","doi":"10.1093/hmg/ddh027","title":"Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis","year":2003,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Canadian Institutes of Health Research","funders":"National Center for Research Resources; Directorate for Biological Sciences; Canadian Institutes of Health Research; Killam Trusts; National Institutes of Health; University of Alberta","keywords":"Biology; Caenorhabditis elegans; Cytochrome c oxidase; Mitochondrion; Oxidative stress; Respiratory chain; Mitochondrial respiratory chain; Biochemistry; Mitochondrial disease; Mitochondrial DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001263737,0.0003237436,0.0002805941,0.0001945601,0.0002150288,0.00006402963,0.0001926828,0.0002469117,0.0001091284],"category_scores_gemma":[0.0003670845,0.0003655438,0.00009335866,0.0002625708,0.0002871913,0.000008235919,0.00009406032,0.0002068486,0.00001920438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003784187,"about_ca_system_score_gemma":0.0001196894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003031578,"about_ca_topic_score_gemma":0.0003519744,"domain_scores_codex":[0.9976422,0.0005074338,0.0003941999,0.0007916077,0.0002160014,0.0004485437],"domain_scores_gemma":[0.9989165,0.00003843914,0.000140966,0.0005552219,0.0001819102,0.0001669785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006604801,0.0001684058,0.001042537,0.00002532564,0.00003129149,0.000080108,0.0002899339,0.000217338,0.9967622,0.0009344254,0.0002408906,0.0001414721],"study_design_scores_gemma":[0.002257277,0.001119589,0.02002132,0.00002843996,0.00009010747,0.0001632359,0.0005001189,0.00002469925,0.9689839,0.0004795175,0.005682525,0.0006492826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911238,0.0009387995,0.005954438,0.00007858895,0.0002642219,0.0006404107,0.0001037018,0.00001858524,0.0008774731],"genre_scores_gemma":[0.9935666,0.0000898487,0.005046133,0.0003173056,0.0001221398,0.0001010048,0.000382108,0.0000511939,0.0003236919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02777834,"threshold_uncertainty_score":0.9998797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01739701233979824,"score_gpt":0.2707618865655571,"score_spread":0.2533648742257588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}