{"id":"W2124322010","doi":"10.1124/mol.113.088229","title":"Hepatocyte Nuclear Factors 4α and 1α Regulate Kidney Developmental Expression of Drug-Metabolizing Enzymes and Drug Transporters","year":2013,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; University of California, San Diego","keywords":"Drug; Transporter; Hepatocyte; Drug metabolism; Hepatocyte nuclear factors; Enzyme; Biology; Drug development; Kidney; Cell biology; ATP-binding cassette transporter; Pharmacology; Biochemistry; Chemistry; Gene expression; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003260715,0.0003317732,0.0003849154,0.0008616787,0.000379316,0.000870423,0.0002681007,0.000271566,0.002396548],"category_scores_gemma":[0.0004559176,0.0003886876,0.0004441136,0.0003165368,0.0005435352,0.0005839833,0.0005122073,0.0006324421,0.0004538595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001545987,"about_ca_system_score_gemma":0.001012899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004784463,"about_ca_topic_score_gemma":0.007947354,"domain_scores_codex":[0.9994705,0.0001047706,0.0000293546,0.00007796527,0.0001432642,0.0001742569],"domain_scores_gemma":[0.9995186,0.00005680308,0.0001697604,0.00002888995,0.0001153313,0.0001105496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007978774,0.00003326303,0.005499923,0.00006909708,0.00002927317,0.0003315667,0.0001609139,0.0001585423,0.9815059,0.002748602,0.0002707616,0.008394322],"study_design_scores_gemma":[0.00007941435,0.0002577792,0.09501562,0.00002927437,0.00008312344,0.001129053,0.0007122452,0.001454659,0.8819305,0.001337041,0.01793515,0.00003611359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964205,0.01457588,0.0121641,0.0006972644,0.0001390132,0.00004792628,0.0007355504,0.000252447,0.007182825],"genre_scores_gemma":[0.9792396,0.003846532,0.003607094,0.0001466874,0.0000330174,0.00003130715,0.0006633772,0.00007335276,0.01235907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004784463,"threshold_uncertainty_score":0.01121694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00592831726574876,"score_gpt":0.2232605905534695,"score_spread":0.2173322732877207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}