{"id":"W2124373649","doi":"10.1186/1475-2867-8-16","title":"Preclinical evaluation of the antineoplastic action of 5-aza-2'-deoxycytidine and different histone deacetylase inhibitors on human Ewing's sarcoma cells","year":2008,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trichostatin A; Histone deacetylase; Cancer research; Epigenetics; Histone deacetylase inhibitor; Clonogenic assay; Vorinostat; Azacitidine; Phenylbutyrate; Acetylation; DNA methylation; Romidepsin; Histone; Medicine; Biology; Cell culture; Gene expression; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002589853,0.0001283202,0.0001471749,0.00005503857,0.00008618022,0.000004759961,0.0001939087,0.0001072828,0.0001248879],"category_scores_gemma":[0.0001319377,0.0001036525,0.0001052309,0.00005448058,0.0002546936,0.000007082563,0.000119848,0.0001380703,0.000001769304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001758057,"about_ca_system_score_gemma":0.0001624632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001282731,"about_ca_topic_score_gemma":0.00016186,"domain_scores_codex":[0.9984502,0.0001367904,0.0003499902,0.0002863751,0.0006515273,0.0001251265],"domain_scores_gemma":[0.9990771,0.00004557695,0.0002360667,0.0002410619,0.0003464122,0.00005378294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342924,0.0002506309,0.002924244,0.00002933758,0.00004087493,5.583841e-7,0.00008270908,0.0004524892,0.9925684,0.00001504945,0.002663377,0.0008379795],"study_design_scores_gemma":[0.0011661,0.0002142489,0.01461278,0.00005753974,0.00003045277,0.000005281284,0.0000202086,0.0009856374,0.9819345,0.000009187092,0.0008710965,0.00009294795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975558,0.0004623807,0.00003168215,0.00009405542,0.0007277661,0.0002393051,0.00004739017,0.000004124981,0.0008375135],"genre_scores_gemma":[0.9984712,0.0002694261,0.00002479508,0.00002511011,0.000332874,0.00003395881,0.00004740277,0.00001688288,0.0007783575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01168854,"threshold_uncertainty_score":0.4226828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08771794342872184,"score_gpt":0.4003996044951786,"score_spread":0.3126816610664567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}