{"id":"W2124412534","doi":"10.1093/nar/gkg824","title":"Inhibition of pre-mRNA splicing by synthetic branched nucleic acids","year":2003,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; RNA splicing; Nucleic acid; Intron; RNA; Biochemistry; Precursor mRNA; DNA; Oligonucleotide; Molecular biology; Messenger RNA; Exonuclease; Exon; Gene; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001685934,0.0004087731,0.0002303736,0.0001353121,0.00007649946,0.000217054,0.0001919464,0.0002186442,0.0008324419],"category_scores_gemma":[0.0002239329,0.0001185686,0.0002000764,0.0001152055,0.0001266026,0.0001029243,0.0001532166,0.000393093,0.0003020827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001992093,"about_ca_system_score_gemma":0.00015501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002464073,"about_ca_topic_score_gemma":0.0003335204,"domain_scores_codex":[0.9998147,0.00005056406,0.00001937238,0.00003241938,0.00005521937,0.00002772984],"domain_scores_gemma":[0.9998391,0.00004951979,0.00004223849,0.00001573855,0.00002192997,0.00003150955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005440801,0.00001449126,0.00004333563,0.00003400985,0.000004112546,0.00001324303,0.000004691625,0.00011751,0.998264,0.00006742973,0.000008555969,0.001374223],"study_design_scores_gemma":[0.00000685796,0.0003107695,0.0001962075,0.000002961619,0.000004450014,0.00004756234,0.000002374129,0.0004277985,0.998165,0.0000144578,0.0008199614,0.000001705174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827827,0.005293658,0.009036905,0.0000583961,0.00005148908,0.00006939869,0.0002152428,0.00009891972,0.002393338],"genre_scores_gemma":[0.9849558,0.002590896,0.009242123,0.00006175934,0.00001864913,0.00006558266,0.0006667856,0.00002895955,0.002369351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008324419,"threshold_uncertainty_score":0.002784789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02088051876958337,"score_gpt":0.3154665699316177,"score_spread":0.2945860511620343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}