{"id":"W2124420763","doi":"10.1186/ar3338","title":"Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis","year":2011,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Université de Montréal; Arthritis Society; McGill University","keywords":"Bradykinin; Medicine; Osteoarthritis; Antagonism; Endothelin receptor; Nociception; Antagonist; Receptor; Receptor antagonist; Hindlimb; Inflammation; Internal medicine; Pharmacology; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001049333,0.0005781122,0.001283852,0.0004402414,0.0002512719,0.00007146733,0.0002257246,0.0005291559,0.00134698],"category_scores_gemma":[0.0001082721,0.0005531044,0.0001471736,0.0006528555,0.001024877,0.0003542248,0.0001683921,0.001033678,0.00004685331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001126652,"about_ca_system_score_gemma":0.0003565518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009339488,"about_ca_topic_score_gemma":0.00009410923,"domain_scores_codex":[0.9951032,0.0006265627,0.0009611408,0.001278098,0.0007626733,0.001268262],"domain_scores_gemma":[0.9979162,0.0001834473,0.0002349617,0.0006270663,0.0004968224,0.0005415123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003735548,0.0006703664,0.0006815745,0.0000391264,0.00007292089,0.0001231096,0.005856831,3.620407e-8,0.7624482,0.000116003,0.002028248,0.2242281],"study_design_scores_gemma":[0.03302544,0.02100434,0.0002223808,0.000606064,0.00001669458,0.0003392431,0.0008021629,0.0002971961,0.9312521,0.0007843308,0.01100477,0.0006452525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667076,0.02601694,0.0000307264,0.001299232,0.0001485362,0.00341613,0.001717989,0.0000904839,0.0005723566],"genre_scores_gemma":[0.920499,0.07261224,0.003253678,0.0006918006,0.000119034,0.0006564776,0.0002769894,0.0001500033,0.001740816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2235828,"threshold_uncertainty_score":0.999692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05309457138265396,"score_gpt":0.3050474061339709,"score_spread":0.2519528347513169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}