{"id":"W2124431153","doi":"10.1124/jpet.105.087023","title":"Inhibition of High Voltage-Activated Calcium Channels by Spider Toxin PnTx3-6","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Voltage-dependent calcium channel; Neurotoxin; Chemistry; Calcium; Stereochemistry; Patch clamp; Biophysics; Crystallography; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582366,0.0002752101,0.000266596,0.0001607476,0.0001518923,0.0002138523,0.0002667575,0.0002900356,0.00125162],"category_scores_gemma":[0.0001647342,0.0001109647,0.0003374823,0.0001424521,0.0002394593,0.0001680747,0.0002305373,0.0006803332,0.0003206998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002947154,"about_ca_system_score_gemma":0.0002663976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008672411,"about_ca_topic_score_gemma":0.0008811192,"domain_scores_codex":[0.9998616,0.00002059301,0.00001078043,0.00001419918,0.00003600727,0.00005692585],"domain_scores_gemma":[0.9998958,0.00003261578,0.00001989064,0.00001218207,0.000009337057,0.00003015626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003169115,0.00002572116,0.00008552788,0.00001936983,0.000005428968,0.00005745708,0.00001017021,0.00007639381,0.9986131,0.0001261801,0.00002818257,0.000635426],"study_design_scores_gemma":[0.00003267397,0.00027483,0.001256761,0.000003238072,0.000008296447,0.0001704625,0.000009580432,0.001008939,0.9966983,0.00004077257,0.0004938782,0.000002180976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954494,0.0007163868,0.0018418,0.00009263593,0.00002831813,0.00002272045,0.0001331634,0.0000697537,0.001645793],"genre_scores_gemma":[0.9967557,0.0004559223,0.0007262267,0.00003199407,0.000008158196,0.00001779431,0.0001732941,0.00001615831,0.001814786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125162,"threshold_uncertainty_score":0.004187047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02259627802373474,"score_gpt":0.3179307327756857,"score_spread":0.295334454751951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}