{"id":"W2124467041","doi":"10.1242/dev.050195","title":"Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin","year":2010,"lang":"en","type":"article","venue":"Development","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Inner cell mass; Cell biology; CDX2; Cadherin; Cell polarity; Embryo; Embryonic stem cell; Epithelial polarity; Epithelium; Trophoblast; Cell; Blastocyst; Genetics; Gene expression; Embryogenesis; Gene; Placenta; Homeobox","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000870193,0.0003773147,0.0001815597,0.0003535672,0.0001398489,0.0003214154,0.0001317158,0.0002897539,0.001036347],"category_scores_gemma":[0.0001293628,0.0002669837,0.0001556311,0.0001446266,0.0003342334,0.0001938012,0.0002591491,0.0005660477,0.0002245225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001869921,"about_ca_system_score_gemma":0.0001295637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004909568,"about_ca_topic_score_gemma":0.0008520928,"domain_scores_codex":[0.9998778,0.00001361391,0.00001524735,0.00002708762,0.000037869,0.00002827167],"domain_scores_gemma":[0.9998674,0.00002158104,0.00004120112,0.00001689185,0.000007363434,0.00004544701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004909316,0.000005187307,0.0004061095,0.000009368245,0.000002972219,0.0001225567,0.00001275528,0.00002649906,0.9989919,0.0000655788,0.000009003092,0.0002989341],"study_design_scores_gemma":[0.00002768593,0.0001689723,0.06134735,0.000007270099,0.00002752103,0.002555712,0.00006250102,0.0006881151,0.9334589,0.0001051551,0.001544215,0.000006649555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978275,0.0003981899,0.0009051156,0.00002344876,0.000005119437,0.000005036771,0.0001279807,0.00003270294,0.0006748775],"genre_scores_gemma":[0.9959487,0.0003196392,0.0007063003,0.00002424865,0.000003690934,0.00001440187,0.0003457075,0.00001950645,0.002617739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036347,"threshold_uncertainty_score":0.003466904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007024633840304714,"score_gpt":0.2218267027250072,"score_spread":0.2148020688847024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}