{"id":"W2124492882","doi":"10.1152/ajpheart.01356.2005","title":"Restoring depressed HERG K<sup>+</sup> channel function as a mechanism for insulin treatment of abnormal QT prolongation and associated arrhythmias in diabetic rabbits","year":2006,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Canadian Diabetes Association","keywords":"hERG; QT interval; Internal medicine; Medicine; Insulin; Diabetes mellitus; Oxidative stress; Long QT syndrome; Endocrinology; Potassium channel; Cardiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002368494,0.000273123,0.001216695,0.0002627507,0.0001105959,0.000004198112,0.00004333934,0.0001980342,0.000005849271],"category_scores_gemma":[0.00009033016,0.0002343314,0.0002429457,0.0002307995,0.0004202951,0.0001127891,0.0000208827,0.0002584569,0.00000138545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001104558,"about_ca_system_score_gemma":0.0001515419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001341164,"about_ca_topic_score_gemma":0.00000770814,"domain_scores_codex":[0.9981615,0.0002986274,0.0006055024,0.0003976657,0.0001242716,0.000412433],"domain_scores_gemma":[0.9986234,0.0002590715,0.0005711635,0.0001983454,0.0002397106,0.0001082739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002451017,0.0003207948,0.001788426,0.00006123348,0.0002901168,0.00000724927,0.0003717504,0.001794707,0.9918281,0.0003181312,0.00001633748,0.000752149],"study_design_scores_gemma":[0.005205634,0.01054854,0.9572077,0.0001071428,0.0003070307,0.0004321895,0.0003226206,0.001724751,0.01351425,0.01035057,0.00004625089,0.000233314],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982756,0.0009110248,0.00001220923,0.0001932609,0.0001400023,0.0004317201,0.000008308649,0.00001697316,0.00001090375],"genre_scores_gemma":[0.9987216,0.0002426244,0.00009275305,0.0002343853,0.000574568,0.0000570255,0.00003572378,0.00002821736,0.00001308768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9783139,"threshold_uncertainty_score":0.9555755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009032420259921528,"score_gpt":0.2325576776993129,"score_spread":0.2235252574393914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}