{"id":"W2124496841","doi":"10.1186/s13041-015-0129-7","title":"Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes","year":2015,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Robarts Research Institute; National Institutes of Health","keywords":"Pinocytosis; Endosome; Endocytosis; Internalization; Amyloid precursor protein; Cell biology; Alpha secretase; P3 peptide; Lysosome; Amyloid beta; Amyloid (mycology); Chemistry; Biology; Alzheimer's disease; Cell; Biochemistry; Intracellular; Enzyme; Internal medicine; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566355,0.0004065909,0.000317838,0.0003279759,0.0002565017,0.0005034879,0.0003918146,0.0003939917,0.001160802],"category_scores_gemma":[0.000201385,0.0001727932,0.0003103364,0.0001196913,0.0003997056,0.0004377736,0.0002826939,0.0003850675,0.0007484016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002848205,"about_ca_system_score_gemma":0.0001901396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003167475,"about_ca_topic_score_gemma":0.0002664035,"domain_scores_codex":[0.9998468,0.00003502883,0.00001677265,0.00003936017,0.000023282,0.00003867061],"domain_scores_gemma":[0.9998313,0.0000253454,0.00004344964,0.00002120901,0.00002547257,0.00005307931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003271947,0.00002562641,0.0002353739,0.00003503616,0.000005225142,0.00008698212,0.0000328127,0.00007554832,0.9966761,0.0004837239,0.00007528903,0.001941128],"study_design_scores_gemma":[0.00004504634,0.0002138742,0.005043993,0.00000713256,0.00002350173,0.0004455014,0.00006762998,0.002059842,0.9855724,0.0004547506,0.006052298,0.00001404951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848576,0.003793673,0.007006076,0.0002508822,0.0001114643,0.0000300435,0.0003210259,0.0004226137,0.003206788],"genre_scores_gemma":[0.9932862,0.001418729,0.002115909,0.00004086647,0.00002346614,0.00002783667,0.0001692142,0.00006883139,0.002848889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160802,"threshold_uncertainty_score":0.003883243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02496958152802159,"score_gpt":0.2966606948923788,"score_spread":0.2716911133643573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}