{"id":"W2124517592","doi":"10.1161/atvb.35.suppl_1.110","title":"Abstract 110: The Separation of Serum Amyloid A from HDL is Mediated by Heparan Sulfate Through Histidine Dependent Interactions: HDL Function is Enhanced but Amyloid-Fibrils may be the “Price to Pay”¼","year":2015,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Serum amyloid A; Chemistry; Heparan sulfate; Heparin; Circular dichroism; Amyloid (mycology); Glycosaminoglycan; Apolipoprotein B; Biochemistry; Lipoprotein; Histidine; Serum Amyloid A Protein; Cholesterol; Biology; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100696,0.0003708991,0.0001969755,0.0001049528,0.0001491522,0.0003492393,0.00018153,0.0002533638,0.00675025],"category_scores_gemma":[0.00009274081,0.00009010356,0.0002207901,0.0001260963,0.0001323109,0.0002044892,0.0001897688,0.0004387736,0.001998368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002320605,"about_ca_system_score_gemma":0.000152376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005223211,"about_ca_topic_score_gemma":0.00026718,"domain_scores_codex":[0.9999319,0.000008786958,0.000005318481,0.00001471685,0.00002776027,0.00001140886],"domain_scores_gemma":[0.9999424,0.000007696473,0.00001517822,0.000003850224,0.00001549037,0.0000154296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002913748,0.00005536638,0.0004621288,0.0001355291,0.00001154201,0.0001715255,0.00001425284,0.00006665404,0.9898434,0.0002685312,0.0009356265,0.007744173],"study_design_scores_gemma":[0.00004448516,0.0005408612,0.01217655,0.00002060329,0.00003329282,0.0008076134,0.00003419619,0.001409266,0.9673647,0.0004067156,0.01715122,0.00001055351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663532,0.007037808,0.006969825,0.00108718,0.0008392335,0.00008388777,0.001286751,0.0002949557,0.01604712],"genre_scores_gemma":[0.9498394,0.003311564,0.003284662,0.0003762004,0.0001908355,0.00002893728,0.002296882,0.00004833012,0.04062328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00675025,"threshold_uncertainty_score":0.02258188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04084355721830939,"score_gpt":0.3128209506336077,"score_spread":0.2719773934152983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}