{"id":"W2124579197","doi":"10.1128/aac.48.9.3630-3635.2004","title":"Designing Fluoroquinolone Breakpoints for <i>Streptococcus pneumoniae</i> by Using Genetics instead of Pharmacokinetics-Pharmacodynamics","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Manitoba","funders":"","keywords":"Gatifloxacin; Levofloxacin; Streptococcus pneumoniae; Moxifloxacin; Pharmacodynamics; Pharmacokinetics; Breakpoint; Gemifloxacin; Pharmacology; Microbiology; Quinolone; Medicine; Biology; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009925819,0.0005916686,0.0004632839,0.0006145739,0.0002485052,0.0007625089,0.0004147087,0.000636732,0.0004588248],"category_scores_gemma":[0.007759633,0.0003012808,0.0005285454,0.0003128135,0.0004260813,0.0005082795,0.0003267892,0.0006968752,0.0001571318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001006049,"about_ca_system_score_gemma":0.0007552617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002144024,"about_ca_topic_score_gemma":0.002048378,"domain_scores_codex":[0.9990402,0.000373107,0.00009273383,0.0001635496,0.0002320674,0.00009829596],"domain_scores_gemma":[0.9969824,0.001490806,0.0009823744,0.0001664377,0.000278129,0.00009983218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001861198,0.0005588357,0.06552618,0.0004232001,0.0002525523,0.0004734245,0.0003597021,0.4063039,0.4449065,0.004496066,0.000343807,0.07449465],"study_design_scores_gemma":[0.0006362837,0.009094925,0.03702725,0.00009926543,0.0003668475,0.001360902,0.0002218796,0.3079271,0.631161,0.006356636,0.00544918,0.0002986485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9175798,0.0006206537,0.08022047,0.0001929936,0.00001685409,0.0001424527,0.0002839528,0.000272556,0.0006702617],"genre_scores_gemma":[0.966657,0.0001405348,0.03280838,0.00004496693,0.000004802569,0.00006379093,0.0001861759,0.00002695751,0.00006744743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002144024,"threshold_uncertainty_score":0.007299423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02140758738687713,"score_gpt":0.3055910236004846,"score_spread":0.2841834362136075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}