{"id":"W2124596857","doi":"10.1210/jc.2013-1364","title":"Antiproliferative and Proapoptotic Activity of Sunitinib on Endothelial and Anaplastic Thyroid Cancer Cells via Inhibition of Akt and ERK1/2 Phosphorylation and by Down-Regulation of Cyclin-D1","year":2013,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Comprehensive Cancer Network","keywords":"Sunitinib; Anaplastic thyroid cancer; Cancer research; Cyclin D1; Vascular endothelial growth factor; Protein kinase B; Angiogenesis; Vascular endothelial growth factor A; Tyrosine-kinase inhibitor; Medicine; Endocrinology; Internal medicine; Biology; Pharmacology; Phosphorylation; Thyroid cancer; Cancer; Cell cycle; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001191857,0.0002638403,0.0002325318,0.0002149383,0.0001399828,0.0001716681,0.0001095824,0.0001427741,0.001200205],"category_scores_gemma":[0.00007116638,0.00007485465,0.0003172219,0.0001598883,0.00011484,0.0001060673,0.00007247426,0.0002588538,0.0001588141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178988,"about_ca_system_score_gemma":0.0002840019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000574005,"about_ca_topic_score_gemma":0.001314642,"domain_scores_codex":[0.9999008,0.00001337213,0.00001306007,0.00001734954,0.00002959503,0.00002573675],"domain_scores_gemma":[0.9999522,0.000008299113,0.00001415682,0.000005080733,0.000009175843,0.000011062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005098185,0.00008196914,0.0009534388,0.0001981264,0.00003078959,0.00009121506,0.00001564628,0.0001351742,0.9904014,0.00008204789,0.0001459344,0.007354439],"study_design_scores_gemma":[0.00008763303,0.001164594,0.02339851,0.000009357843,0.0000640612,0.0009716717,0.00002695111,0.0007791386,0.9691209,0.00004395445,0.004326549,0.000006545787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878335,0.008510078,0.001154159,0.00007963455,0.00004499283,0.00002273263,0.0003261683,0.00005551663,0.001973172],"genre_scores_gemma":[0.9955206,0.00225888,0.0008520437,0.0000348309,0.00001264323,0.00001788816,0.0003363279,0.000003981952,0.0009627278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200205,"threshold_uncertainty_score":0.004015088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183091428678355,"score_gpt":0.3197232732898627,"score_spread":0.2978923590030791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}