{"id":"W2124597635","doi":"10.1160/th15-04-0336","title":"Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway","year":2015,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Factor XII; Nucleic acid; Thrombin; DNA; RNA; Chemistry; Biochemistry; Prekallikrein; Coagulation; High-molecular-weight kininogen; Molecular biology; Kallikrein; Cell biology; Kininogen; Biology; Enzyme; Gene; Immunology; Platelet; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004238951,0.0002579366,0.0004408786,0.000107927,0.0002945271,0.0001023092,0.00006421568,0.0001073406,0.00002677206],"category_scores_gemma":[0.0001442089,0.0001695811,0.00004458099,0.0002787116,0.0002224518,0.000186359,0.0001119974,0.0001306084,0.000006787742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005676591,"about_ca_system_score_gemma":0.00005023665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006455145,"about_ca_topic_score_gemma":0.0001153669,"domain_scores_codex":[0.9987587,0.00006709626,0.0002768256,0.0003785812,0.0002414808,0.0002772665],"domain_scores_gemma":[0.9989876,0.0001334141,0.000109435,0.00028517,0.0001608336,0.0003235129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0007347898,0.000278564,0.2455591,0.0002449428,0.0004916782,0.000008623301,0.02867959,0.000008130748,0.05826621,0.003962368,0.00565557,0.6561104],"study_design_scores_gemma":[0.002857751,0.0006596096,0.8355083,0.0002305909,0.0002555488,0.00005941096,0.00178058,0.0004201295,0.143539,0.002403214,0.01182482,0.000461032],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891654,0.001321745,0.00006270594,0.008230696,0.0001059789,0.0006052414,0.00004494925,0.0000653872,0.0003978923],"genre_scores_gemma":[0.9981515,0.0003413474,0.0003656797,0.0007481655,0.0001863759,0.00003109629,0.00002372447,0.00002868353,0.000123422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6556494,"threshold_uncertainty_score":0.6915316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1108763202386296,"score_gpt":0.2947734485074915,"score_spread":0.1838971282688619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}