{"id":"W2124597635","doi":"10.1160/th15-04-0336","title":"Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway","year":2015,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Factor XII; Nucleic acid; Thrombin; DNA; RNA; Chemistry; Biochemistry; Prekallikrein; Coagulation; High-molecular-weight kininogen; Molecular biology; Kallikrein; Cell biology; Kininogen; Biology; Enzyme; Gene; Immunology; Platelet; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570851,0.0004093987,0.0002744664,0.0002424153,0.00005885047,0.0001916567,0.0001664092,0.0002845052,0.001257639],"category_scores_gemma":[0.0001220478,0.0001144515,0.0001940808,0.00007328859,0.0002867272,0.0001678338,0.0001385488,0.0004461663,0.0002077188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686701,"about_ca_system_score_gemma":0.00007742189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002039331,"about_ca_topic_score_gemma":0.0002437652,"domain_scores_codex":[0.9998041,0.00005934906,0.00001181335,0.00004062715,0.00003722174,0.0000469848],"domain_scores_gemma":[0.9998374,0.00002866904,0.00005713664,0.00001841969,0.000009011494,0.00004929471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001082772,0.0000155423,0.00008675682,0.00001347036,0.000003918464,0.00004257996,0.00000485873,0.00001357419,0.9991824,0.00004346577,0.00001084435,0.0004742765],"study_design_scores_gemma":[0.00002356932,0.0008899237,0.004608285,0.00000320808,0.00001656335,0.0003094587,0.00001291876,0.0002971472,0.9928973,0.00003561231,0.00090332,0.0000026281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970498,0.000933969,0.001271306,0.00005852778,0.00001213221,0.00001160832,0.00007676863,0.00005461068,0.0005313025],"genre_scores_gemma":[0.9968815,0.000426382,0.00125732,0.00004466789,0.00001144753,0.00001356031,0.0001308083,0.00001170962,0.001222695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257639,"threshold_uncertainty_score":0.004207194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1108763202386296,"score_gpt":0.2947734485074915,"score_spread":0.1838971282688619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}