{"id":"W2124620798","doi":"10.2174/1567205011310030006","title":"Therapeutic Effects of Quetiapine on Memory Deficit and Brain β-Amyloid Plaque Pathology in a Transgenic Mouse Model of Alzheimer’s Disease","year":2013,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Quetiapine; Neuropathology; Genetically modified mouse; Presenilin; Amyloid precursor protein; Alzheimer's disease; Transgene; Amyloid beta; GSK-3; Medicine; Pharmacology; Pathology; Schizophrenia (object-oriented programming); Chemistry; Disease; Kinase; Psychiatry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004897316,0.0002218351,0.000301619,0.0003292818,0.00005839525,0.00001637448,0.0002946895,0.0001538524,0.00004716489],"category_scores_gemma":[0.0001761695,0.0002051841,0.0001263531,0.0001892212,0.0003764623,0.00001446989,0.0001520326,0.0004726325,0.00002835985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001398707,"about_ca_system_score_gemma":0.0001749992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001157293,"about_ca_topic_score_gemma":0.00006683182,"domain_scores_codex":[0.9977164,0.0005630135,0.0003943258,0.0005202881,0.0003431129,0.0004628052],"domain_scores_gemma":[0.9986706,0.0001839374,0.00009331584,0.0006264775,0.0002373815,0.0001882207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003273353,0.0006505007,0.0007539545,0.0001702094,0.0002526861,0.000001599367,0.0002381386,0.0003546793,0.9850559,0.000270933,0.0007329079,0.01119118],"study_design_scores_gemma":[0.001649448,0.0006282634,0.0034078,0.0001724176,0.0001465827,0.000003284111,0.00004727167,0.001302663,0.9908971,0.0008481902,0.0005808802,0.0003160811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621322,0.03520216,0.0003717651,0.0006650199,0.00007248933,0.001427897,0.00004226258,0.000008716698,0.000077504],"genre_scores_gemma":[0.9977236,0.001314261,0.0001409084,0.00004711705,0.00004527083,0.0005192362,0.00007458081,0.00004188329,0.00009310711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03559145,"threshold_uncertainty_score":0.8367166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042536382253797,"score_gpt":0.385661435943984,"score_spread":0.2814077977186044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}