{"id":"W2124631799","doi":"10.1128/jvi.01164-10","title":"Identification of Novel Mutations Responsible for Resistance to MK-2048, a Second-Generation HIV-1 Integrase Inhibitor","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Elvitegravir; Biology; Integrase; Raltegravir; Viral replication; Mutagenesis; In silico; Mutation; Point mutation; Virus; Virology; Genetics; Molecular biology; Gene; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000790602,0.0005081677,0.0003288902,0.0001942083,0.0001116264,0.0002481695,0.0003587176,0.0004342865,0.001149821],"category_scores_gemma":[0.0002573541,0.0001383684,0.0003670883,0.0001377531,0.0001680973,0.0001185419,0.0001764774,0.0005734024,0.000398982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002255464,"about_ca_system_score_gemma":0.0001594846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003294453,"about_ca_topic_score_gemma":0.0004846033,"domain_scores_codex":[0.9999013,0.00001273112,0.00001133745,0.0000208757,0.00003758705,0.00001622038],"domain_scores_gemma":[0.9998827,0.00002557294,0.00004365727,0.00001121021,0.00001419891,0.00002268798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002012344,0.00008645704,0.002509624,0.00004013136,0.00002093777,0.0008251657,0.0000311665,0.0002877815,0.9895425,0.0001310478,0.00008143876,0.00624259],"study_design_scores_gemma":[0.0001317988,0.001240438,0.0308913,0.00001986153,0.00008670511,0.01687662,0.0001044372,0.006170105,0.9387621,0.0001792811,0.005500147,0.00003710728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967355,0.000247848,0.001762832,0.00005306343,0.00001892668,0.00006310153,0.0004539909,0.00006377585,0.0006009498],"genre_scores_gemma":[0.9954999,0.0001588928,0.002870794,0.00003608639,0.000008406168,0.00002353293,0.0006184739,0.00003391222,0.0007500082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149821,"threshold_uncertainty_score":0.003846586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02040213939468007,"score_gpt":0.3068717380530017,"score_spread":0.2864695986583216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}