{"id":"W2124652213","doi":"10.1111/j.1747-4949.2011.00608.x","title":"The Membrane-Activated Chelator Stroke Intervention (MACSI) Trial of DP-b99 in Acute Ischemic Stroke: A Randomized, Double-Blind, Placebo-Controlled, Multinational Pivotal Phase III Study","year":2011,"lang":"en","type":"article","venue":"International Journal of Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Stroke (engine); Modified Rankin Scale; Placebo; Randomized controlled trial; Clinical trial; Interim analysis; Clinical endpoint; Neuroprotection; Anesthesia; Internal medicine; Ischemia; Ischemic stroke; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001745356,0.002039619,0.00267621,0.000384256,0.0004510397,0.0008925297,0.0009831078,0.00195214,0.003968052],"category_scores_gemma":[0.001466748,0.0004581301,0.0009807667,0.0004615755,0.001054768,0.0007849924,0.0003728401,0.002298181,0.0008558583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005068745,"about_ca_system_score_gemma":0.001221153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006867507,"about_ca_topic_score_gemma":0.001190128,"domain_scores_codex":[0.9994891,0.0002676284,0.00003273698,0.00007438714,0.00006031136,0.0000757869],"domain_scores_gemma":[0.9993837,0.0001047552,0.0001644747,0.00006409793,0.00007091713,0.0002120559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9691198,0.007850078,0.001052455,0.0009185574,0.0008500154,0.00006178455,0.00006280954,0.0002206786,0.00592626,0.000203568,0.001529288,0.01220471],"study_design_scores_gemma":[0.9525265,0.04324715,0.002246436,0.00004524985,0.0004096034,0.00004143455,0.00001247052,0.0002261627,0.0004741526,0.0001220049,0.0006377915,0.00001113021],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824497,0.005842959,0.0007280784,0.001235306,0.0003345523,0.00541524,0.00126897,0.0001216203,0.002603516],"genre_scores_gemma":[0.9731243,0.00450872,0.00272266,0.00232662,0.0007976345,0.01046379,0.002399893,0.00003313428,0.003623233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003968052,"threshold_uncertainty_score":0.01327449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02842419905380713,"score_gpt":0.331111012709869,"score_spread":0.3026868136560619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}