{"id":"W2124668663","doi":"10.1158/2326-6066.cir-14-0222","title":"Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy","year":2015,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Hospital for Sick Children","keywords":"T-cell receptor; Chemistry; Major histocompatibility complex; Antigen; T cell; Biology; Epitope; Molecular biology; Cell biology; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997472,0.0003426312,0.0002224198,0.0002006614,0.00008414748,0.0003556969,0.0001653796,0.0001893616,0.0006779924],"category_scores_gemma":[0.0001362559,0.000136835,0.0001527177,0.000174667,0.0001431256,0.0002098619,0.0001902941,0.0005348626,0.0001891714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195598,"about_ca_system_score_gemma":0.0001816632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001103169,"about_ca_topic_score_gemma":0.0002252846,"domain_scores_codex":[0.9998094,0.00003428415,0.00001700153,0.000035576,0.00005254304,0.00005108182],"domain_scores_gemma":[0.9998863,0.00002177373,0.00004634018,0.00001187369,0.0000123649,0.0000213432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002626826,0.00001975467,0.00008442051,0.00001327648,0.000002164087,0.000009107264,0.000004759147,0.0002464494,0.998673,0.00006045593,0.000007826269,0.0008525669],"study_design_scores_gemma":[0.00001954895,0.0004726526,0.001158365,0.000005700887,0.00003015801,0.0001749782,0.00001618689,0.002610822,0.9937649,0.00006043408,0.001680517,0.000005678071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98883,0.001060506,0.009025238,0.00004682194,0.00001281042,0.00004003373,0.00007456331,0.0000665658,0.0008434024],"genre_scores_gemma":[0.9945875,0.0008865087,0.003774149,0.00003205906,0.000009159628,0.00002986452,0.00009645784,0.00001722694,0.0005669463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006779924,"threshold_uncertainty_score":0.002268136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09014275203993506,"score_gpt":0.3906313593916063,"score_spread":0.3004886073516712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}