{"id":"W2124672367","doi":"10.1371/journal.pone.0070536","title":"Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Health and Medical Research Council; Ministero dello Sviluppo Economico; Medical Research Council; National Institutes of Health; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Pfizer; Johns Hopkins University; Eli Lilly and Company","keywords":"SOCS5; SOCS3; Autophosphorylation; Suppressor of cytokine signaling 1; Janus kinase; SOCS6; Cell biology; Signal transducing adaptor protein; Biology; Signal transduction; Cytokine receptor; Janus kinase 1; JAK-STAT signaling pathway; Cytokine; Tyrosine kinase 2; Suppressor of cytokine signalling; Tyrosine kinase; Suppressor; Receptor; Kinase; Biochemistry; Growth factor; STAT3; Protein kinase A; Immunology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001934573,0.0004053643,0.0002114966,0.0002514578,0.0001879142,0.0004180853,0.0001500444,0.0001814989,0.001359906],"category_scores_gemma":[0.0001166752,0.00009951504,0.0004155435,0.0001370702,0.000326536,0.0002126358,0.0003692162,0.0003180972,0.0003129206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004331085,"about_ca_system_score_gemma":0.0002151417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004139462,"about_ca_topic_score_gemma":0.0008189307,"domain_scores_codex":[0.9998228,0.00003148885,0.00001733155,0.00002980974,0.00004171857,0.00005693694],"domain_scores_gemma":[0.9998862,0.00001019474,0.00004905494,0.000009948424,0.000006896502,0.00003772294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001405662,0.00001762939,0.0009762422,0.00005829044,0.0000119319,0.0001436558,0.00001763733,0.000210861,0.9944338,0.0007650455,0.0000564729,0.003167873],"study_design_scores_gemma":[0.00007804409,0.000852771,0.02789513,0.00002417981,0.00006081808,0.00240774,0.00006828466,0.005211083,0.9497029,0.0002713948,0.01340763,0.00002006461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928352,0.002155324,0.003174627,0.00006429032,0.00002832198,0.0000211534,0.0001807605,0.00007062002,0.001469741],"genre_scores_gemma":[0.9976777,0.0002676662,0.00115545,0.0000404331,0.000006193394,0.000007515235,0.000199994,0.00000456613,0.0006404768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001359906,"threshold_uncertainty_score":0.004549325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04584855246052558,"score_gpt":0.2496181486937742,"score_spread":0.2037695962332487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}