{"id":"W2124672367","doi":"10.1371/journal.pone.0070536","title":"Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Health and Medical Research Council; Ministero dello Sviluppo Economico; Medical Research Council; National Institutes of Health; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Pfizer; Johns Hopkins University; Eli Lilly and Company","keywords":"SOCS5; SOCS3; Autophosphorylation; Suppressor of cytokine signaling 1; Janus kinase; SOCS6; Cell biology; Signal transducing adaptor protein; Biology; Signal transduction; Cytokine receptor; Janus kinase 1; JAK-STAT signaling pathway; Cytokine; Tyrosine kinase 2; Suppressor of cytokine signalling; Tyrosine kinase; Suppressor; Receptor; Kinase; Biochemistry; Growth factor; STAT3; Protein kinase A; Immunology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001139099,0.0001063235,0.0002717598,0.00007003317,0.00006992932,0.00001501517,0.00004524262,0.00003984381,0.0001914864],"category_scores_gemma":[0.0001757368,0.00006658796,0.00005415997,0.00009346881,0.00009185002,0.0001536887,0.00001884786,0.0001054452,0.000001406805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002285492,"about_ca_system_score_gemma":0.00002898131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001643884,"about_ca_topic_score_gemma":0.00002404243,"domain_scores_codex":[0.9992096,0.00002741838,0.0002739029,0.0001531377,0.0002229595,0.0001130032],"domain_scores_gemma":[0.998916,0.0002147968,0.0002410858,0.0001905272,0.0003927806,0.00004481693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006017418,0.0005891558,0.000832643,0.000372602,0.0002087711,2.208526e-7,0.0002972135,0.000008592031,0.996522,0.0001772446,0.0001371815,0.000252622],"study_design_scores_gemma":[0.001026642,0.001026291,0.007695455,0.00109919,0.0003299914,0.000005133465,0.0003855521,0.004113057,0.9840089,0.00009497269,0.0001407541,0.00007402971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954494,0.00003708733,0.001542439,0.001122827,0.00001293186,0.00147432,0.0000640644,0.00002217912,0.0002747239],"genre_scores_gemma":[0.9957017,0.000002896682,0.003602339,0.00002348101,0.000119524,0.0002331883,0.00004271147,0.00002032099,0.0002537874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01251308,"threshold_uncertainty_score":0.2715378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04584855246052558,"score_gpt":0.2496181486937742,"score_spread":0.2037695962332487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}