{"id":"W2124714673","doi":"10.1158/0008-5472.can-06-4336","title":"Elevated Frequencies of Self-reactive CD8+ T Cells following Immunization with a Xenoantigen Are Due to the Presence of a Heteroclitic CD4+ T-Cell Helper Epitope","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"McMaster University","keywords":"Epitope; Immunogenicity; CD8; T cell; Cytotoxic T cell; Immunology; Immunization; Antigen; Biology; Immunity; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382437,0.0004925947,0.0002762337,0.0003014414,0.00008474338,0.0002398435,0.0001434233,0.0003661785,0.001492891],"category_scores_gemma":[0.0001602769,0.0001904338,0.0001876666,0.0001146092,0.000246593,0.0001944761,0.0002223099,0.0009281859,0.0004671797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002019408,"about_ca_system_score_gemma":0.00009731379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001256489,"about_ca_topic_score_gemma":0.000164572,"domain_scores_codex":[0.999796,0.00002921762,0.00001749469,0.00005821427,0.00003966561,0.00005939716],"domain_scores_gemma":[0.9997614,0.00004935414,0.00006851699,0.0000412223,0.00001415964,0.00006531469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008360203,0.00002067708,0.0003389233,0.00001272978,0.000002508258,0.00002953249,0.000006357605,0.00001733391,0.9989723,0.00002365049,0.000009976958,0.0004825025],"study_design_scores_gemma":[0.00004224158,0.001129629,0.0125144,0.00000819739,0.0000331048,0.0008554382,0.00002907103,0.0009985314,0.9833817,0.0001110449,0.0008916655,0.000005011738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971295,0.0004139041,0.001433125,0.00002902977,0.00001748107,0.00002252703,0.00008610346,0.00009387964,0.0007743775],"genre_scores_gemma":[0.9973541,0.0002011873,0.001062632,0.00003695358,0.00001935536,0.00002754028,0.0001965639,0.00001764249,0.001084007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001492891,"threshold_uncertainty_score":0.004994214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.026244699398194,"score_gpt":0.3138550345029631,"score_spread":0.2876103351047691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}